Combining deep mutational scanning to heatmap of HLA class II binding of immunogenic sequences to preserve functionality and mitigate predicted immunogenicity

Removal of CD4 T cell epitopes from therapeutic antibody sequences is expected to mitigate their potential immunogenicity, but its application is complicated by the location of their T cell epitopes, which mainly overlap with complementarity-determining regions. We therefore evaluated the flexibilit...

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Detalles Bibliográficos
Autores principales: Sivelle, Coline, Sierocki, Raphael, Lesparre, Youen, Lomet, Aurore, Quintilio, Wagner, Dubois, Steven, Correia, Evelyne, Moro, Ana Maria, Maillère, Bernard, Nozach, Hervé
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416631/
https://www.ncbi.nlm.nih.gov/pubmed/37575221
http://dx.doi.org/10.3389/fimmu.2023.1197919

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416631/
https://www.ncbi.nlm.nih.gov/pubmed/37575221
http://dx.doi.org/10.3389/fimmu.2023.1197919

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