TGFβ Inhibitor A83-01 Enhances Murine HSPC Expansion for Gene Therapy

Murine hematopoietic stem and progenitor cells (HSPCs) are commonly used as model systems during gene therapeutic retroviral vector development and preclinical biosafety assessment. Here, we developed cell culture conditions to maintain stemness and prevent differentiation during HSPC culture. We us...

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Detalles Bibliográficos
Autores principales: Fleischauer, Jenni, Bastone, Antonella Lucia, Selich, Anton, John-Neek, Philipp, Weisskoeppel, Luisa, Schaudien, Dirk, Schambach, Axel, Rothe, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416825/
https://www.ncbi.nlm.nih.gov/pubmed/37566057
http://dx.doi.org/10.3390/cells12151978

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416825/
https://www.ncbi.nlm.nih.gov/pubmed/37566057
http://dx.doi.org/10.3390/cells12151978

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