The Bivalent Bromodomain Inhibitor MT-1 Inhibits Prostate Cancer Growth

SIMPLE SUMMARY: MT-1 decreased cell viability and causes cell cycle arrest in G0/G1 phase in castration sensitive and resistant PC cell lines in a dose-dependent fashion. The inhibition of c-Myc function by MT-1 was molecularly corroborated by de-repression of Protein Kinase D1 (PrKD) and increased...

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Detalles Bibliográficos
Autores principales: Shukla, Sanjeev, Riveros, Carlos, Al-Toubat, Mohammed, Chardon-Robles, Jonathan, Osumi, Teruko, Serrano, Samuel, Kase, Adam M., Petit, Joachim L., Meurice, Nathalie, Gleba, Justyna, Copland, John A., Chauhan, Jay, Fletcher, Steven, Balaji, K. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416835/
https://www.ncbi.nlm.nih.gov/pubmed/37568667
http://dx.doi.org/10.3390/cancers15153851

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416835/
https://www.ncbi.nlm.nih.gov/pubmed/37568667
http://dx.doi.org/10.3390/cancers15153851

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