Genetic Downregulation of the Metabotropic Glutamate Receptor Type 5 Dampens the Reactive and Neurotoxic Phenotype of Adult ALS Astrocytes

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive degeneration of motor neurons (MNs). Astrocytes display a toxic phenotype in ALS, which results in MN damage. Glutamate (Glu)-mediated excitotoxicity and group I metabotropic glutamate receptors (mG...

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Detalles Bibliográficos
Autores principales: Torazza, Carola, Provenzano, Francesca, Gallia, Elena, Cerminara, Maria, Balbi, Matilde, Bonifacino, Tiziana, Tessitore, Sara, Ravera, Silvia, Usai, Cesare, Musante, Ilaria, Puliti, Aldamaria, Van Den Bosch, Ludo, Jafar-nejad, Paymaan, Rigo, Frank, Milanese, Marco, Bonanno, Giambattista
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416852/
https://www.ncbi.nlm.nih.gov/pubmed/37566031
http://dx.doi.org/10.3390/cells12151952

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416852/
https://www.ncbi.nlm.nih.gov/pubmed/37566031
http://dx.doi.org/10.3390/cells12151952

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