G4-QuadScreen: A Computational Tool for Identifying Multi-Target-Directed Anticancer Leads against G-Quadruplex DNA

SIMPLE SUMMARY: G-quadruplexes (G4s) are guanine-rich, four-stranded nucleic acid structures that are abundantly found in the promoter region of various oncogenes (cMYC, cKIT, KRAS, etc.) and in the telomeric region. The ligand-induced stabilization of G4s is shown to be efficient in targeted cancer...

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Detalles Bibliográficos
Autores principales: Bhat-Ambure, Jyotsna, Ambure, Pravin, Serrano-Candelas, Eva, Galiana-Roselló, Cristina, Gil-Martínez, Ariadna, Guerrero, Mario, Martin, Margarita, González-García, Jorge, García-España, Enrique, Gozalbes, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416877/
https://www.ncbi.nlm.nih.gov/pubmed/37568632
http://dx.doi.org/10.3390/cancers15153817

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416877/
https://www.ncbi.nlm.nih.gov/pubmed/37568632
http://dx.doi.org/10.3390/cancers15153817

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