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G4-QuadScreen: A Computational Tool for Identifying Multi-Target-Directed Anticancer Leads against G-Quadruplex DNA

SIMPLE SUMMARY: G-quadruplexes (G4s) are guanine-rich, four-stranded nucleic acid structures that are abundantly found in the promoter region of various oncogenes (cMYC, cKIT, KRAS, etc.) and in the telomeric region. The ligand-induced stabilization of G4s is shown to be efficient in targeted cancer...

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Detalles Bibliográficos
Autores principales:	Bhat-Ambure, Jyotsna, Ambure, Pravin, Serrano-Candelas, Eva, Galiana-Roselló, Cristina, Gil-Martínez, Ariadna, Guerrero, Mario, Martin, Margarita, González-García, Jorge, García-España, Enrique, Gozalbes, Rafael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416877/ https://www.ncbi.nlm.nih.gov/pubmed/37568632 http://dx.doi.org/10.3390/cancers15153817

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