C9orf72 Toxic Species Affect ArfGAP-1 Function

Compelling evidence indicates that defects in nucleocytoplasmic transport contribute to the pathogenesis of amyotrophic lateral sclerosis (ALS). In particular, hexanucleotide (G4C2) repeat expansions in C9orf72, the most common cause of genetic ALS, have a widespread impact on the transport machiner...

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Detalles Bibliográficos
Autores principales: Rossi, Simona, Di Salvio, Michela, Balì, Marilisa, De Simone, Assia, Apolloni, Savina, D’Ambrosi, Nadia, Arisi, Ivan, Cipressa, Francesca, Cozzolino, Mauro, Cestra, Gianluca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416972/
https://www.ncbi.nlm.nih.gov/pubmed/37566088
http://dx.doi.org/10.3390/cells12152007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416972/
https://www.ncbi.nlm.nih.gov/pubmed/37566088
http://dx.doi.org/10.3390/cells12152007

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