CD40L Activates Platelet Integrin αIIbβ3 by Binding to the Allosteric Site (Site 2) in a KGD-Independent Manner and HIGM1 Mutations Are Clustered in the Integrin-Binding Sites of CD40L

CD40L is expressed in activated T cells, and it plays a major role in immune response and is a major therapeutic target for inflammation. High IgM syndrome type 1 (HIGM1) is a congenital functional defect in CD40L/CD40 signaling due to defective CD40L. CD40L is also stored in platelet granules and t...

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Detalles Bibliográficos
Autores principales: Takada, Yoko K., Shimoda, Michiko, Takada, Yoshikazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416995/
https://www.ncbi.nlm.nih.gov/pubmed/37566056
http://dx.doi.org/10.3390/cells12151977

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416995/
https://www.ncbi.nlm.nih.gov/pubmed/37566056
http://dx.doi.org/10.3390/cells12151977

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