Cargando…

Tumor Mutational Burden in Breast Cancer: Current Evidence, Challenges, and Opportunities

SIMPLE SUMMARY: The tumor mutational burden (TMB) can be defined as the number of somatic mutations per megabase of the sequenced genome. It correlates with tumor neoantigen burden, T cell infiltration, and response to immune checkpoint inhibitors in many solid tumor types. In addition, TMB has been...

Descripción completa

Detalles Bibliográficos
Autores principales:	Barroso-Sousa, Romualdo, Pacífico, Jana Priscila, Sammons, Sarah, Tolaney, Sara M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417019/ https://www.ncbi.nlm.nih.gov/pubmed/37568813 http://dx.doi.org/10.3390/cancers15153997

Ejemplares similares

Concurrent predictors of an immune responsive tumor microenvironment within tumor mutational burden-high breast cancer
por: Sammons, Sarah, et al.
Publicado: (2023)

Evidence to date: talazoparib in the treatment of breast cancer
por: Exman, Pedro, et al.
Publicado: (2019)

Clinical Development of New Antibody–Drug Conjugates in Breast Cancer: To Infinity and Beyond
por: Barroso-Sousa, Romualdo, et al.
Publicado: (2021)

Tissue-agnostic drug approvals: how does this apply to patients with breast cancer?
por: Weis, Luiza N., et al.
Publicado: (2021)

Tumor mutational burden as a predictor of immunotherapy response in breast cancer
por: O’Meara, Tess A., et al.
Publicado: (2021)

OR19-5 The Impact Of High Dose Glucocorticoids On The Outcome Of Immune Checkpoint Inhibitor-related Thyroid Disorders And The Baseline TSH As A Predictive Biomarker
por: Min, Le, et al.
Publicado: (2019)

Disease Burden: Progresses Made, Current State, Future Challenges, and Opportunities
por: Wang, Haidong
Publicado: (2022)

Neoadjuvant endocrine therapy in breast cancer: current role and future perspectives
por: Barroso-Sousa, Romualdo, et al.
Publicado: (2016)

Filling the Gap after CDK4/6 Inhibitors: Novel Endocrine and Biologic Treatment Options for Metastatic Hormone Receptor Positive Breast Cancer
por: Mittal, Abhenil, et al.
Publicado: (2023)

Chlamydia trachomatis as a Current Health Problem: Challenges and Opportunities
por: Rodrigues, Rafaela, et al.
Publicado: (2022)

CDK4/6 inhibition in breast cancer: current practice and future directions
por: Pernas, Sonia, et al.
Publicado: (2018)

Growing Burden of Hypertension in China: Causes, Challenges, and Opportunities
por: Shi, Zumin, et al.
Publicado: (2020)

Obesity pandemic in China: epidemiology, burden, challenges, and opportunities
por: Li, Jing, et al.
Publicado: (2022)

Editorial to the Special Issue “Food Bioactives: Chemical Challenges and Bio-Opportunities”
por: Pacifico, Severina, et al.
Publicado: (2021)

Diabetic Complications: Current Challenges and Opportunities
por: Nickerson, Helen D., et al.
Publicado: (2012)

Metallic Biomaterials: Current Challenges and Opportunities
por: Prasad, Karthika, et al.
Publicado: (2017)

Current Challenges and Opportunities in Treating Glioblastoma
por: Shergalis, Andrea, et al.
Publicado: (2018)

CAR T cell therapy and the tumor microenvironment: Current challenges and opportunities
por: Kankeu Fonkoua, Lionel A., et al.
Publicado: (2022)

Current Evidence, Challenges, and Opportunities of Physiologically Based Pharmacokinetic Models of Atorvastatin for Decision Making
por: Reig-López, Javier, et al.
Publicado: (2021)

Modeling clonal structure over narrow time frames via circulating tumor DNA in metastatic breast cancer
por: Weber, Zachary T., et al.
Publicado: (2021)

Challenges in bioinformatics approaches to tumor mutation burden analysis
por: Fenizia, Francesca, et al.
Publicado: (2021)

Reducing the Cancer Burden of Lifestyle Factors: Opportunities and Challenges of the Internet
por: Graham, Amanda L, et al.
Publicado: (2005)

Ecopharmacovigilance: Current state, challenges, and opportunities in China
por: Wang, Jun, et al.
Publicado: (2014)

Translational Metabolomics: Current Challenges and Future Opportunities
por: Pinu, Farhana R., et al.
Publicado: (2019)

Estrogens in schizophrenia: progress, current challenges and opportunities
por: Brand, Bodyl A., et al.
Publicado: (2021)

Current epidemiology of pancreatic cancer: Challenges and opportunities
por: Luo, Wenhao, et al.
Publicado: (2020)

Chronic Diabetic Complications: Current Challenges and Opportunities
por: Migdalis, Ilias N., et al.
Publicado: (2022)

Maternal vaccination—current status, challenges, and opportunities
por: Kurasawa, Kentaro
Publicado: (2022)

Current Challenges and Opportunities for Improved Cannabidiol Solubility
por: Hossain, Khondker Rufaka, et al.
Publicado: (2023)

Current perspectives on the immunosuppressive tumor microenvironment in hepatocellular carcinoma: challenges and opportunities
por: Lu, Chen, et al.
Publicado: (2019)

Tumor mutational burden quantification from targeted gene panels: major advancements and challenges
por: Fancello, Laura, et al.
Publicado: (2019)

Dual burden of Zika and COVID-19 in India: challenges, opportunities and recommendations
por: Bardhan, Mainak, et al.
Publicado: (2021)

Prevention of mental disorders: evidence, challenges and opportunities
por: Jacka, Felice N, et al.
Publicado: (2014)

Immunotherapy for the Treatment of Triple-Negative Breast Cancer
por: Tolaney, Sara M., et al.
Publicado: (2022)

Multiple Papillomas of the Breast: A Review of Current Evidence and Challenges
por: Rella, Rossella, et al.
Publicado: (2022)

The health of Saudi youths: current challenges and future opportunities
por: Moradi-Lakeh, Maziar, et al.
Publicado: (2016)

National health inequality monitoring: current challenges and opportunities
por: Hosseinpoor, Ahmad Reza, et al.
Publicado: (2018)

Opportunities and challenges in the current era of global medical education
por: Rizwan, Muhammad, et al.
Publicado: (2018)

Subcutaneous Administration of Biotherapeutics: An Overview of Current Challenges and Opportunities
por: Bittner, Beate, et al.
Publicado: (2018)

Rethinking cancer: current challenges and opportunities in cancer research
por: Cagan, Ross, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_fb02d2bepa0b7usslbk1fjle6v