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Androgen receptor knockdown enhances prostate cancer chemosensitivity by down‐regulating FEN1 through the ERK/ELK1 signalling pathway

PURPOSE: Flap endonuclease 1 (FEN1) is highly upregulated in prostate cancer and promotes the growth of prostate cancer cells. Androgen receptor (AR) is the most critical determinant of the occurrence, progression, metastasis, and treatment of prostate cancer. However, the effect of FEN1 on docetaxe...

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Detalles Bibliográficos
Autores principales: Xie, Weijie, Li, Shulin, Guo, Huan, Zhang, Jiawei, Tu, Menjiang, Wang, Rui, Lin, Bingling, Wu, Yuqi, Wang, Xiangwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417077/
https://www.ncbi.nlm.nih.gov/pubmed/37326412
http://dx.doi.org/10.1002/cam4.6188