Establishment and Molecular Characterization of an In Vitro Model for PARPi-Resistant Ovarian Cancer

SIMPLE SUMMARY: We established an in vitro model for PARPi-resistant ovarian cancer by long-term olaparib exposure of either BRCA1-proficient or BRCA1-deficient cell lines. We describe that PARPi-resistant cells show a broad spectrum of cross-resistance toward other clinically relevant PARPis and ch...

Descripción completa

Detalles Bibliográficos
Autores principales: Klotz, Daniel Martin, Schwarz, Franziska Maria, Dubrovska, Anna, Schuster, Kati, Theis, Mirko, Krüger, Alexander, Kutz, Oliver, Link, Theresa, Wimberger, Pauline, Drukewitz, Stephan, Buchholz, Frank, Thomale, Jürgen, Kuhlmann, Jan Dominik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417418/
https://www.ncbi.nlm.nih.gov/pubmed/37568590
http://dx.doi.org/10.3390/cancers15153774

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417418/
https://www.ncbi.nlm.nih.gov/pubmed/37568590
http://dx.doi.org/10.3390/cancers15153774

Ejemplares similares