Interruption of p53-MDM2 Interaction by Nutlin-3a in Human Lymphoma Cell Models Initiates a Cell-Dependent Global Effect on Transcriptome and Proteome Level

SIMPLE SUMMARY: The activation of wild-type p53 protein in human lymphoma is a promising therapeutic strategy. A precise interruption of a protein–protein interaction, such as the p53-MDM2 interaction by nutlin-3a may lead lymphoma cells to apoptotic death through the stabilization and activation of...

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Detalles Bibliográficos
Autores principales: Psatha, Konstantina, Kollipara, Laxmikanth, Drakos, Elias, Deligianni, Elena, Brintakis, Konstantinos, Patsouris, Eustratios, Sickmann, Albert, Rassidakis, George Z., Aivaliotis, Michalis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417430/
https://www.ncbi.nlm.nih.gov/pubmed/37568720
http://dx.doi.org/10.3390/cancers15153903

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417430/
https://www.ncbi.nlm.nih.gov/pubmed/37568720
http://dx.doi.org/10.3390/cancers15153903

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