Cargando…

StemRegenin-1 Attenuates Endothelial Progenitor Cell Senescence by Regulating the AhR Pathway-Mediated CYP1A1 and ROS Generation

Endothelial progenitor cell (EPC)-based stem cell therapy is a promising therapeutic strategy for vascular diseases. However, continuous in vitro expansion for clinical studies induces the loss of EPC functionality due to aging. In this study, we investigated the effects of StemRegenin-1 (SR-1), an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lim, Hye Ji, Jang, Woong Bi, Rethineswaran, Vinoth Kumar, Choi, Jaewoo, Lee, Eun Ji, Park, Sangmi, Jeong, Yeoreum, Ha, Jong Seong, Yun, Jisoo, Choi, Young Jin, Hong, Young Joon, Kwon, Sang-Mo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417434/ https://www.ncbi.nlm.nih.gov/pubmed/37566085 http://dx.doi.org/10.3390/cells12152005

Ejemplares similares

Reducing TGF‐β1 cooperated with StemRegenin 1 promoted the expansion ex vivo of cord blood CD34(+) cells by inhibiting AhR signalling
por: Zhu, Xuejun, et al.
Publicado: (2021)

StemRegenin 1 selectively promotes expansion of Multipotent Hematopoietic Progenitors derived from Human Embryonic Stem Cells
por: Tao, Lihong, et al.
Publicado: (2017)

StemRegenin 1 Mitigates Radiation-Mediated Hematopoietic Injury by Modulating Radioresponse of Hematopoietic Stem/Progenitor Cells
por: Hwang, You Jung, et al.
Publicado: (2023)

Enhanced generation of cord blood hematopoietic stem and progenitor cells by culture with StemRegenin1 and Delta1(Ext-IgG)
por: Dahlberg, Ann, et al.
Publicado: (2014)

Serotonin Modulates AhR Activation by Interfering with CYP1A1-Mediated Clearance of AhR Ligands
por: Manzella, Christopher R., et al.
Publicado: (2020)

Serotonin is an endogenous regulator of intestinal CYP1A1 via AhR
por: Manzella, Christopher, et al.
Publicado: (2018)

NUPR1 contributes to radiation resistance by maintaining ROS homeostasis via AhR/CYP signal axis in hepatocellular carcinoma
por: Zhan, Yizhi, et al.
Publicado: (2022)

The Protective Role of Glutathione against Doxorubicin-Induced Cardiotoxicity in Human Cardiac Progenitor Cells
por: Lee, Eun Ji, et al.
Publicado: (2023)

AhR activation underlies the CYP1A autoinduction by A-998679 in rats
por: Liguori, Michael J., et al.
Publicado: (2012)

Effect of TBT and PAHs on CYP1A, AhR and Vitellogenin Gene Expression in the Japanese Eel, Anguilla japonica
por: Choi, Min Seop, et al.
Publicado: (2012)

Coactivator Recruitment of AhR/ARNT1
por: Endler, Alexander, et al.
Publicado: (2014)

Sp1, Instead of AhR, Regulates the Basal Transcription of Porcine CYP1A1 at the Proximal Promoter
por: Xie, Xuan, et al.
Publicado: (2018)

Transgenic Overexpression of Aryl Hydrocarbon Receptor Repressor (AhRR) and AhR-Mediated Induction of CYP1A1, Cytokines, and Acute Toxicity
por: Vogel, Christoph F.A., et al.
Publicado: (2016)

The Landscape of AhR Regulators and Coregulators to Fine-Tune AhR Functions
por: Gargaro, Marco, et al.
Publicado: (2021)

Taxifolin suppresses the malignant progression of gastric cancer by regulating the AhR/CYP1A1 signaling pathway
por: Xie, Jiebin, et al.
Publicado: (2021)

AhR promotes phosphorylation of ARNT isoform 1 in human T cell malignancies as a switch for optimal AhR activity
por: Bourner, Luke A., et al.
Publicado: (2022)

Mitochondrial activity and oxidative stress functions are influenced by the activation of AhR-induced CYP1A1 overexpression in cardiomyocytes
por: Zhou, Bing, et al.
Publicado: (2017)

AhR and IDO1 in pathogenesis of Covid-19 and the “Systemic AhR Activation Syndrome:” a translational review and therapeutic perspectives
por: Turski, Waldemar A., et al.
Publicado: (2020)

ZNF165 Is Involved in the Regulation of Immune Microenvironment and Promoting the Proliferation and Migration of Hepatocellular Carcinoma by AhR/CYP1A1
por: Liu, Peng, et al.
Publicado: (2022)

AhR-Mediated, Non-Genomic Modulation of IDO1 Function
por: Pallotta, Maria Teresa, et al.
Publicado: (2014)

The Coevolution of IDO1 and AhR in the Emergence of Regulatory T-Cells in Mammals
por: Grohmann, Ursula, et al.
Publicado: (2015)

Tumor-Suppressive Functions of the Aryl Hydrocarbon Receptor (AhR) and AhR as a Therapeutic Target in Cancer
por: Elson, Daniel J., et al.
Publicado: (2023)

Taxifolin Inhibits 7,12-Dimethylbenz(a)anthracene-induced Breast Carcinogenesis by Regulating AhR/CYP1A1 Signaling Pathway
por: Haque, Md. Wasimul, et al.
Publicado: (2017)

Tryptophan Feeding of the IDO1-AhR Axis in Host–Microbial Symbiosis
por: Zelante, Teresa, et al.
Publicado: (2014)

The Role of Aryl-Hydrocarbon Receptor (AhR) in Osteoclast Differentiation and Function
por: Park, Robin, et al.
Publicado: (2020)

AhR signaling pathways and regulatory functions
por: Larigot, Lucie, et al.
Publicado: (2018)

Epigenetic Regulations of AhR in the Aspect of Immunomodulation
por: Wajda, Anna, et al.
Publicado: (2020)

The neuroprotective action of 3,3′-diindolylmethane against ischemia involves an inhibition of apoptosis and autophagy that depends on HDAC and AhR/CYP1A1 but not ERα/CYP19A1 signaling
por: Rzemieniec, J., et al.
Publicado: (2019)

Ethyl Caffeate Can Inhibit Aryl Hydrocarbon Receptor (AhR) Signaling and AhR-Mediated Potentiation of Mast Cell Activation
por: Nguyen, Phuc-Tan, et al.
Publicado: (2023)

AhR and HIF-1α Signaling Pathways in Benign Meningioma under Hypoxia
por: Perepechaeva, Maria L., et al.
Publicado: (2023)

Dimethyl sulfoxide stimulates the AhR-Jdp2 axis to control ROS accumulation in mouse embryonic fibroblasts
por: Wuputra, Kenly, et al.
Publicado: (2021)

Amyloid β neurotoxicity is IDO1–Kyn–AhR dependent and blocked by IDO1 inhibitor
por: Duan, Zhenzhen, et al.
Publicado: (2020)

Interaction between AhR and HIF-1 signaling pathways mediated by ARNT/HIF-1β
por: Zhang, Mengdi, et al.
Publicado: (2022)

PAHs Target Hematopoietic Linages in Bone Marrow through Cyp1b1 Primarily in Mesenchymal Stromal Cells but Not AhR: A Reconstituted In Vitro Model
por: Rondelli, Catherine M., et al.
Publicado: (2016)

Roles for B[a]P and FICZ in subchondral bone metabolism and experimental temporomandibular joint osteoarthritis via the AhR/Cyp1a1 signaling axis
por: Yoshikawa, Yuri, et al.
Publicado: (2021)

Role of AhR/ARNT system in skin homeostasis
por: Furue, Masutaka, et al.
Publicado: (2014)

Bidirectional talk between AhR and Oct4
por: Kang, Bo, et al.
Publicado: (2015)

Induction of AhR-Mediated Gene Transcription by Coffee
por: Ishikawa, Toshio, et al.
Publicado: (2014)

New Treatments in Renal Cancer: The AhR Ligands
por: Itkin, Boris, et al.
Publicado: (2020)

Herbal Plants: The Role of AhR in Mediating Immunomodulation
por: Bungsu, Izzah, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_a0ooage8kcpvi0mcibjpqj772b