Cargando…

The Multikinase Inhibitor AD80 Induces Mitotic Catastrophe and Autophagy in Pancreatic Cancer Cells

SIMPLE SUMMARY: Pancreatic cancer is one of the most lethal human neoplasms, and its therapeutic repertoire remains limited. Advances in understanding the molecular complexity involved in the biology of the disease have paved the way for new therapeutic opportunities. AD80 is a multikinase inhibitor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lima, Keli, de Miranda, Lívia Bassani Lins, Del Milagro Bernabe Garnique, Anali, de Almeida, Bruna Oliveira, do Nascimento, Mariane Cristina, Alcântara, Guilherme Augusto Sousa, Machado-Santelli, Glaucia Maria, Rego, Eduardo Magalhães, Machado-Neto, João Agostinho
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417629/ https://www.ncbi.nlm.nih.gov/pubmed/37568682 http://dx.doi.org/10.3390/cancers15153866

Ejemplares similares

Data mining in acute myeloid leukemia: identification of disease biomarkers, prognostic factors, novel targets, and potential drugs
por: Machado-Neto, João Agostinho, et al.
Publicado: (2023)

Telomerase inhibitors TMPyP4 and thymoquinone decreased cell proliferation and induced cell death in the non-small cell lung cancer cell line LC-HK2, modifying the pattern of focal adhesion
por: Garnique, A.M.B., et al.
Publicado: (2023)

NT157 exerts antineoplastic activity by targeting JNK and AXL signaling in lung cancer cells
por: de Miranda, Lívia Bassani Lins, et al.
Publicado: (2022)

Targeting glioma cells by antineoplastic activity of reversine
por: Hirakata, Camila, et al.
Publicado: (2021)

Involvement of autophagy in the outcome of mitotic catastrophe
por: Sorokina, Irina V., et al.
Publicado: (2017)

Role of senescence and mitotic catastrophe in cancer therapy
por: Singh, Richa, et al.
Publicado: (2010)

Targeting the Mitotic Catastrophe Signaling Pathway in Cancer
por: Mc Gee, Margaret M.
Publicado: (2015)

Necroptosis as a Novel Facet of Mitotic Catastrophe
por: Egorshina, Aleksandra Yu., et al.
Publicado: (2022)

PB1826: CELLULAR AND MOLECULAR CHARACTERIZATION OF THE ANTINEOPLASTIC EFFECTS OF CEPHALOCHROMIN IN MODELS OF ACUTE MYELOID LEUKEMIA
por: Nascimento, Mariane Cristina Do, et al.
Publicado: (2023)

A link between mitotic defects and mitotic catastrophe: detection and cell fate
por: Sazonova, Elena V., et al.
Publicado: (2021)

Cinnamic acid induces apoptotic cell death and cytoskeleton disruption in human melanoma cells
por: Niero, Evandro Luís de Oliveira, et al.
Publicado: (2013)

Chrysotile effects on human lung cell carcinoma in culture: 3-D reconstruction and DNA quantification by image analysis
por: Cortez, Beatriz A, et al.
Publicado: (2008)

An automated fluorescence videomicroscopy assay for the detection of mitotic catastrophe
por: Rello-Varona, S, et al.
Publicado: (2010)

Retraction: Role of senescence and mitotic catastrophe in cancer therapy
por: Singh, Richa, et al.
Publicado: (2012)

BETi induction of mitotic catastrophe: towing the LIN9
por: Gayle, Sylvia S., et al.
Publicado: (2017)

Daily Management of Patients on Multikinase Inhibitors’ Treatment
por: Colombo, Carla, et al.
Publicado: (2022)

The histone genes cluster in Rhynchosciara americana and its transcription profile in salivary glands during larval development
por: Siviero, Fábio, et al.
Publicado: (2016)

Multikinase Inhibitor Treatment in Thyroid Cancer
por: Ancker, Ole Vincent, et al.
Publicado: (2019)

Rare complications of multikinase inhibitor treatment
por: Pitoia, Fabián, et al.
Publicado: (2018)

Mitotic catastrophe and cell death induced by depletion of centrosomal proteins
por: Kimura, M, et al.
Publicado: (2013)

The effect of paclitaxel on apoptosis, autophagy and mitotic catastrophe in AGS cells
por: Khing, Tin Myo, et al.
Publicado: (2021)

The Fate of Chrysotile-Induced Multipolar Mitosis and Aneuploid Population in Cultured Lung Cancer Cells
por: Cortez, Beatriz de Araujo, et al.
Publicado: (2011)

Mitotic phosphorylation of histone H3 threonine 80
por: Hammond, Sharra L, et al.
Publicado: (2014)

Timing of multikinase inhibitor initiation in differentiated thyroid cancer
por: Brose, Marcia S, et al.
Publicado: (2017)

Mitotic Spindle Disruption by Alternating Electric Fields Leads to Improper Chromosome Segregation and Mitotic Catastrophe in Cancer Cells
por: Giladi, Moshe, et al.
Publicado: (2015)

Escaping death to quiescence: Avoiding mitotic catastrophe after DNA damage
por: Shen, Zhiyuan, et al.
Publicado: (2013)

Mitotic catastrophe triggered in human cancer cells by the viral protein apoptin
por: Lanz, H L, et al.
Publicado: (2013)

Polyoma small T antigen triggers cell death via mitotic catastrophe
por: Fernando, Arun T Pores, et al.
Publicado: (2014)

Growth hormone induces mitotic catastrophe of glomerular podocytes and contributes to proteinuria
por: Nishad, Rajkishor, et al.
Publicado: (2021)

CENPE Inhibition Leads to Mitotic Catastrophe and DNA Damage in Medulloblastoma Cells
por: Iegiani, Giorgia, et al.
Publicado: (2021)

Myelosuppression and kinase selectivity of multikinase angiogenesis inhibitors
por: Kumar, R, et al.
Publicado: (2009)

Inositol polyphosphate multikinase signaling in the regulation of metabolism
por: Lee, Joo-Young, et al.
Publicado: (2012)

Multikinase inhibitors use in differentiated thyroid carcinoma
por: Jasim, Sina, et al.
Publicado: (2014)

Depletion of pre-mRNA splicing factor Cdc5L inhibits mitotic progression and triggers mitotic catastrophe
por: Mu, R, et al.
Publicado: (2014)

P347: PHARMACOLOGICAL EZRIN INHIBITION REDUCES GROWTH, ADHESION, MIGRATION AND REGULATE GENE RELATED TO APOPTOSIS AND CELL CYCLE IN ACUTE LYMPHOBLASTIC LEUKAEMIA
por: Carlos Lipreri Da Silva, Jean, et al.
Publicado: (2023)

Retinal pigment epithelial cells undergoing mitotic catastrophe are vulnerable to autophagy inhibition
por: Lee, S Y, et al.
Publicado: (2014)

BI2536 induces mitotic catastrophe and radiosensitization in human oral cancer cells
por: Cheng, Chieh-Yuan, et al.
Publicado: (2018)

Co-delivery of paclitaxel and cetuximab by nanodiamond enhances mitotic catastrophe and tumor inhibition
por: Lin, Yu-Wei, et al.
Publicado: (2017)

Mitotic Catastrophe in BC3H1 Cells following Yessotoxin Exposure
por: Korsnes, Mónica Suárez, et al.
Publicado: (2017)

Biology of Glioblastoma Multiforme—Exploration of Mitotic Catastrophe as a Potential Treatment Modality
por: Vitovcova, Barbora, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_96sde9jrbclhsqpcdqkjmd5vtk