TAp73 Inhibits EMT and Cell Migration in Pancreatic Cancer Cells through Promoting SMAD4 Expression and SMAD4-Dependent Inhibition of ERK Activation

SIMPLE SUMMARY: Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease due to early metastatic spread, late diagnosis and the lack of efficient therapies. The aim of our study was to reveal if transcriptionally active p73 (TAp73), a homolog of the well-known tumor suppressor p53, inhibits tumor...

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Detalles Bibliográficos
Autores principales: Ungefroren, Hendrik, Konukiewitz, Björn, Braun, Rüdiger, Wellner, Ulrich Friedrich, Lehnert, Hendrik, Marquardt, Jens-Uwe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417771/
https://www.ncbi.nlm.nih.gov/pubmed/37568607
http://dx.doi.org/10.3390/cancers15153791

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417771/
https://www.ncbi.nlm.nih.gov/pubmed/37568607
http://dx.doi.org/10.3390/cancers15153791

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