Cargando…

TAp73 Inhibits EMT and Cell Migration in Pancreatic Cancer Cells through Promoting SMAD4 Expression and SMAD4-Dependent Inhibition of ERK Activation

SIMPLE SUMMARY: Pancreatic ductal adenocarcinoma (PDAC) is a fatal disease due to early metastatic spread, late diagnosis and the lack of efficient therapies. The aim of our study was to reveal if transcriptionally active p73 (TAp73), a homolog of the well-known tumor suppressor p53, inhibits tumor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ungefroren, Hendrik, Konukiewitz, Björn, Braun, Rüdiger, Wellner, Ulrich Friedrich, Lehnert, Hendrik, Marquardt, Jens-Uwe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417771/ https://www.ncbi.nlm.nih.gov/pubmed/37568607 http://dx.doi.org/10.3390/cancers15153791

Ejemplares similares

Elucidation of the Role of SMAD4 in Epithelial–Mesenchymal Plasticity: Does It Help to Better Understand the Consequences of DPC4 Inactivation in the Malignant Progression of Pancreatic Ductal Adenocarcinoma?
por: Ungefroren, Hendrik, et al.
Publicado: (2023)

Suppressive Role of ACVR1/ALK2 in Basal and TGFβ1-Induced Cell Migration in Pancreatic Ductal Adenocarcinoma Cells and Identification of a Self-Perpetuating Autoregulatory Loop Involving the Small GTPase RAC1b
por: Ungefroren, Hendrik, et al.
Publicado: (2022)

A Comparative Endocrine Trans-Differentiation Approach to Pancreatic Ductal Adenocarcinoma Cells with Different EMT Phenotypes Identifies Quasi-Mesenchymal Tumor Cells as Those with Highest Plasticity
por: Schmidtlein, Paula M., et al.
Publicado: (2021)

The Quasimesenchymal Pancreatic Ductal Epithelial Cell Line PANC-1—A Useful Model to Study Clonal Heterogeneity and EMT Subtype Shifting
por: Ungefroren, Hendrik, et al.
Publicado: (2022)

Differential roles of Smad2 and Smad3 in the regulation of TGF-β1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1
por: Ungefroren, Hendrik, et al.
Publicado: (2011)

RAC1B Induces SMAD7 via USP26 to Suppress TGFβ1-Dependent Cell Migration in Mesenchymal-Subtype Carcinoma Cells
por: Ungefroren, Hendrik, et al.
Publicado: (2020)

Activation of a Ductal-to-Endocrine Transdifferentiation Transcriptional Program in the Pancreatic Cancer Cell Line PANC-1 Is Controlled by RAC1 and RAC1b through Antagonistic Regulation of Stemness Factors
por: Schmidtlein, Paula Marie, et al.
Publicado: (2021)

Autocrine TGFβ1 Opposes Exogenous TGFβ1-Induced Cell Migration and Growth Arrest through Sustainment of a Feed-Forward Loop Involving MEK-ERK Signaling
por: Ungefroren, Hendrik, et al.
Publicado: (2021)

Negative Control of Cell Migration by Rac1b in Highly Metastatic Pancreatic Cancer Cells Is Mediated by Sequential Induction of Nonactivated Smad3 and Biglycan
por: Otterbein, Hannah, et al.
Publicado: (2019)

The Small GTPase RAC1B: A Potent Negative Regulator of-and Useful Tool to Study-TGFβ Signaling
por: Ungefroren, Hendrik, et al.
Publicado: (2020)

RAC1B Regulation of TGFB1 Reveals an Unexpected Role of Autocrine TGFβ1 in the Suppression of Cell Motility
por: Ungefroren, Hendrik, et al.
Publicado: (2020)

Dasatinib blocks transcriptional and promigratory responses to transforming growth factor-beta in pancreatic adenocarcinoma cells through inhibition of Smad signalling: implications for in vivo mode of action
por: Bartscht, Tobias, et al.
Publicado: (2015)

Differential Effects of Somatostatin, Octreotide, and Lanreotide on Neuroendocrine Differentiation and Proliferation in Established and Primary NET Cell Lines: Possible Crosstalk with TGF-β Signaling
por: Ungefroren, Hendrik, et al.
Publicado: (2022)

Rac1b negatively regulates TGF-β1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling
por: Ungefroren, Hendrik, et al.
Publicado: (2013)

The Use of PDX1 DNA Methylation to Distinguish Two Subtypes of Pancreatic Neuroendocrine Neoplasms with Different Prognoses
por: Ungefroren, Hendrik, et al.
Publicado: (2022)

GABARAPL1 Inhibits EMT Signaling through SMAD-Tageted Negative Feedback
por: Jacquet, Marine, et al.
Publicado: (2021)

Smad4 is required to inhibit osteoclastogenesis and maintain bone mass
por: Morita, Mayu, et al.
Publicado: (2016)

SMAD4 activates Wnt signaling pathway to inhibit granulosa cell apoptosis
por: Du, Xing, et al.
Publicado: (2020)

Establishment and Molecular Characterization of Two Patient-Derived Pancreatic Ductal Adenocarcinoma Cell Lines as Preclinical Models for Treatment Response
por: Braun, Rüdiger, et al.
Publicado: (2023)

TGF-Beta Induced Erk Phosphorylation of Smad Linker Region Regulates Smad Signaling
por: Hough, Chris, et al.
Publicado: (2012)

Deletion of miR-15a inhibited glioma development via targeting Smad7 and inhibiting EMT pathway
por: Guo, Yanfeng, et al.
Publicado: (2021)

Alcohol Activates TGF-Beta but Inhibits BMP Receptor-Mediated Smad Signaling and Smad4 Binding to Hepcidin Promoter in the Liver
por: Gerjevic, Lisa Nicole, et al.
Publicado: (2012)

TrkB-Induced Inhibition of R-SMAD/SMAD4 Activation is Essential for TGF-β-Mediated Tumor Suppressor Activity
por: Kim, Min Soo, et al.
Publicado: (2020)

SnoN Stabilizes the SMAD3/SMAD4 Protein Complex
por: Walldén, Karin, et al.
Publicado: (2017)

Bone morphogenetic protein 4 inhibits rat stem/progenitor Leydig cell development and regeneration via SMAD-dependent and SMAD-independent signaling
por: Li, Xiaoheng, et al.
Publicado: (2022)

The Role of PAR2 in TGF-β1-Induced ERK Activation and Cell Motility
por: Ungefroren, Hendrik, et al.
Publicado: (2017)

Chinese 1 strain of Toxoplasma gondii excreted–secreted antigens negatively modulate Foxp3 via inhibition of the TGFßRII/Smad2/Smad3/Smad4 pathway
por: Chen, Jinling, et al.
Publicado: (2017)

Autophagy inhibition potentiates the anti-EMT effects of alteronol through TGF-β/Smad3 signaling in melanoma cells
por: Bao, Yong, et al.
Publicado: (2020)

Zili Inhibits Transforming Growth Factor-β Signaling by Interacting with Smad4
por: Sun, Huaqin, et al.
Publicado: (2010)

Nimesulide inhibits the proliferation of HepG2 by up-regulation of Smad4
por: Yang, Shaoqi, et al.
Publicado: (2012)

TRAF4 Inhibits Bladder Cancer Progression by Promoting BMP/SMAD Signaling
por: Iyengar, Prasanna Vasudevan, et al.
Publicado: (2022)

TGF-β-MTA1-SMAD7-SMAD3-SOX4-EZH2 Signaling Axis Promotes Viability, Migration, Invasion and EMT of Hepatocellular Carcinoma Cells
por: Zhang, Kangjun, et al.
Publicado: (2021)

PLK2 phosphorylates and inhibits enriched TAp73 in human osteosarcoma cells
por: Hu, Zheng Bo, et al.
Publicado: (2015)

Roles of Smads Family and Alternative Splicing Variants of Smad4 in Different Cancers
por: Ullah, Irfan, et al.
Publicado: (2018)

Preclinical Patient-Derived Culture Models for Personalized Treatment of Pancreatic Cancer: A Dream of the Future or Useful Practice?
por: Braun, Rüdiger, et al.
Publicado: (2023)

Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development
por: Tang, Patrick Ming-Kuen, et al.
Publicado: (2017)

SMAD2/3 mediate oncogenic effects of TGF-β in the absence of SMAD4
por: Bertrand-Chapel, Adrien, et al.
Publicado: (2022)

Polydatin prevents bleomycin-induced pulmonary fibrosis by inhibiting the TGF-β/Smad/ERK signaling pathway
por: Liu, Yan-Lu, et al.
Publicado: (2020)

No SMAD4 hypermethylation in colorectal cancer
por: Roth, S, et al.
Publicado: (2000)

miR-452-3p inhibited osteoblast differentiation by targeting Smad4
por: Wu, Ming, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_vlc6kapip0kctikdie3ao7ifbm