Recent Progress in Modulation of WD40-Repeat Domain 5 Protein (WDR5): Inhibitors and Degraders

SIMPLE SUMMARY: WD40-repeat (WDR) domain proteins play a crucial role in mediating protein–protein interactions that sustain oncogenesis in human cancers. WDR5 has two protein interaction sites, the “WDR5-binding motif” (WBM) site for MYC interaction and the histone methyltransferases SET1 recogniti...

Descripción completa

Detalles Bibliográficos
Autores principales: Gurung, Raju, Om, Darlami, Pun, Rabin, Hyun, Soonsil, Shin, Dongyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417795/
https://www.ncbi.nlm.nih.gov/pubmed/37568727
http://dx.doi.org/10.3390/cancers15153910

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417795/
https://www.ncbi.nlm.nih.gov/pubmed/37568727
http://dx.doi.org/10.3390/cancers15153910

Ejemplares similares