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Efficient encoding of large antigenic spaces by epitope prioritization with Dolphyn

We investigated a relatively underexplored component of the gut-immune axis by profiling the antibody response to gut phages using Phage Immunoprecipitation Sequencing (PhIP-Seq). To enhance this approach, we developed Dolphyn, a novel method that uses machine learning to select peptides from protei...

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Detalles Bibliográficos
Autores principales: Liebhoff, Anna-Maria, Venkataraman, Thiagarajan, Morgenlander, William R, Na, Miso, Kula, Tomasz, Waugh, Kathleen, Morrison, Charles, Rewers, Marian, Longman, Randy, Round, June, Elledge, Stephen, Ruczinski, Ingo, Langmead, Ben, Larman, H Benjamin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418057/
https://www.ncbi.nlm.nih.gov/pubmed/37577562
http://dx.doi.org/10.1101/2023.07.30.551179