Selective inhibition of hsp90 paralogs: Structure and binding studies uncover the role of helix 1 in Grp94-selective ligand binding

Grp94 is the endoplasmic reticulum paralog of the hsp90 family of chaperones, which have been targeted for therapeutic intervention via their highly conserved ATP binding sites. The design of paralog-selective inhibitors relies on understanding the structural elements that mediate each paralog’s res...

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Detalles Bibliográficos
Autores principales: Que, Nanette L. S., Seidler, Paul M., Aw, Wen J., Chiosis, Gabriela, Gewirth, Daniel T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418071/
https://www.ncbi.nlm.nih.gov/pubmed/37577523
http://dx.doi.org/10.1101/2023.07.31.551342

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418071/
https://www.ncbi.nlm.nih.gov/pubmed/37577523
http://dx.doi.org/10.1101/2023.07.31.551342

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