Disordered C-terminal domain drives spatiotemporal confinement of RNAPII to enhance search for chromatin targets

Efficient gene expression requires RNA Polymerase II (RNAPII) to find chromatin targets precisely in space and time. How RNAPII manages this complex diffusive search in 3D nuclear space remains largely unknown. The disordered carboxy-terminal domain (CTD) of RNAPII, which is essential for recruiting...

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Detalles Bibliográficos
Autores principales: Ling, Yick Hin, Ye, Joseph, Yu, Chuofan, Liang, Chloe, Park, Giho, Corden, Jeffry, Wu, Carl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418089/
https://www.ncbi.nlm.nih.gov/pubmed/37577667
http://dx.doi.org/10.1101/2023.07.31.551302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418089/
https://www.ncbi.nlm.nih.gov/pubmed/37577667
http://dx.doi.org/10.1101/2023.07.31.551302

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