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Biophysical principles predict fitness of SARS-CoV-2 variants

SARS-CoV-2 employs its spike protein’s receptor binding domain (RBD) to enter host cells. The RBD is constantly subjected to immune responses, while requiring efficient binding to host cell receptors for successful infection. However, understanding how RBD’s biophysical properties contribute to SARS...

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Detalles Bibliográficos
Autores principales: Wang, Dianzhuo, Huot, Marian, Mohanty, Vaibhav, Shakhnovich, Eugene I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418099/
https://www.ncbi.nlm.nih.gov/pubmed/37577536
http://dx.doi.org/10.1101/2023.07.23.549087