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MicroED as a powerful tool for structure determination of macrocyclic drug compounds directly from their powder formulations
Macrocycles are important drug leads with many advantages including the ability to target flat and featureless binding sites as well as act as molecular chameleons and thereby reach intracellular targets. However, due to their complex structures and inherent flexibility, macrocycles are difficult to...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418104/ https://www.ncbi.nlm.nih.gov/pubmed/37577574 http://dx.doi.org/10.1101/2023.07.31.551405 |