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Acetic acid is a superior acidifier for sub-nanogram and single cell proteomic studies
A recent study demonstrated a substantial signal increase when employing a 0.5% acetic acid buffer additive instead of the traditional 0.1% formic acid used in shotgun proteomics. In this study I compare these two buffers for a dilution series of tryptic digests down to 20 picograms peptide on colum...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418182/ https://www.ncbi.nlm.nih.gov/pubmed/37577694 http://dx.doi.org/10.1101/2023.08.01.551522 |