Oxidative rearrangement of tryptophan to indole nitrile by a single diiron enzyme

Nitriles are uncommon in nature and are typically constructed from oximes via the oxidative decarboxylation of amino acid substrates or from the derivatization of carboxylic acids. Here we report a third strategy of nitrile biosynthesis featuring the cyanobacterial nitrile synthase AetD. During the...

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Detalles Bibliográficos
Autores principales: Adak, Sanjoy, Ye, Naike, Calderone, Logan A., Schäfer, Rebecca J. B., Lukowski, April L., Pandelia, Maria-Eirini, Drennan, Catherine L., Moore, Bradley S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418191/
https://www.ncbi.nlm.nih.gov/pubmed/37577561
http://dx.doi.org/10.1101/2023.08.03.551874

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418191/
https://www.ncbi.nlm.nih.gov/pubmed/37577561
http://dx.doi.org/10.1101/2023.08.03.551874

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