Mis-splicing Drives Loss of Function of p53(E224D) Point Mutation

BACKGROUND: Tp53 is the most commonly mutated gene in cancer. Canonical Tp53 DNA damage response pathways are well characterized and classically thought to underlie the tumor suppressive effect of Tp53. Challenging this dogma, mouse models have revealed that p53 driven apoptosis and cell cycle arres...

Descripción completa

Detalles Bibliográficos
Autores principales: Lock, Ian C., Leisenring, Nathan H., Floyd, Warren, Xu, Eric S., Luo, Lixia, Ma, Yan, Mansell, Erin C., Cardona, Diana M., Lee, Chang-Lung, Kirsch, David G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418211/
https://www.ncbi.nlm.nih.gov/pubmed/37577531
http://dx.doi.org/10.1101/2023.08.01.551439

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418211/
https://www.ncbi.nlm.nih.gov/pubmed/37577531
http://dx.doi.org/10.1101/2023.08.01.551439

Ejemplares similares