Flexibility and distributive synthesis regulate RNA priming and handoff in human DNA polymerase α-primase

DNA replication in eukaryotes relies on the synthesis of a ~30-nucleotide RNA/DNA primer strand through the dual action of the heterotetrameric polymerase α-primase (pol-prim) enzyme. Synthesis of the 7-10-nucleotide RNA primer is regulated by the C-terminal domain of the primase regulatory subunit...

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Detalles Bibliográficos
Autores principales: Cordoba, John J., Mullins, Elwood A., Salay, Lauren E., Eichman, Brandt F., Chazin, Walter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418221/
https://www.ncbi.nlm.nih.gov/pubmed/37577606
http://dx.doi.org/10.1101/2023.08.01.551538

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418221/
https://www.ncbi.nlm.nih.gov/pubmed/37577606
http://dx.doi.org/10.1101/2023.08.01.551538

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