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Continuous lifelong learning for modeling of gene regulation from single cell multiome data by leveraging atlas-scale external data

Accurate context-specific Gene Regulatory Networks (GRNs) inference from genomics data is a crucial task in computational biology. However, existing methods face limitations, such as reliance on gene expression data alone, lower resolution from bulk data, and data scarcity for specific cellular syst...

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Detalles Bibliográficos
Autores principales: Yuan, Qiuyue, Duren, Zhana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418251/
https://www.ncbi.nlm.nih.gov/pubmed/37577525
http://dx.doi.org/10.1101/2023.08.01.551575