Molecular modeling of apoE in complexes with Alzheimer’s amyloid-β fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids

Apolipoproteins co-deposit with amyloids, yet apolipoprotein-amyloid interactions are enigmatic. To understand how apoE interacts with Alzheimer’s amyloid-β (Aβ) peptide in fibrillary deposits, the NMR structure of full-length human apoE was docked to four structures of patient-derived Aβ(1–40) and...

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Detalles Bibliográficos
Autores principales: Lewkowicz, Emily, Nakamura, Mari N., Rynkiewicz, Michael J., Gursky, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418262/
https://www.ncbi.nlm.nih.gov/pubmed/37577501
http://dx.doi.org/10.1101/2023.08.04.551703

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418262/
https://www.ncbi.nlm.nih.gov/pubmed/37577501
http://dx.doi.org/10.1101/2023.08.04.551703

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