A dose-response based model for statistical analysis of chemical genetic interactions in CRISPRi libraries

An important application of CRISPR interference (CRISPRi) technology is for identifying chemical-genetic interactions (CGIs). Discovery of genes that interact with exposure to antibiotics can yield insights to drug targets and mechanisms of action or resistance. The premise is to look for CRISPRi mu...

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Detalles Bibliográficos
Autores principales: Choudhery, Sanjeevani, DeJesus, Michael A., Srinivasan, Aarthi, Rock, Jeremy, Schnappinger, Dirk, Ioerger, Thomas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418283/
https://www.ncbi.nlm.nih.gov/pubmed/37577548
http://dx.doi.org/10.1101/2023.08.03.551759

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418283/
https://www.ncbi.nlm.nih.gov/pubmed/37577548
http://dx.doi.org/10.1101/2023.08.03.551759

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