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A dose-response based model for statistical analysis of chemical genetic interactions in CRISPRi libraries
An important application of CRISPR interference (CRISPRi) technology is for identifying chemical-genetic interactions (CGIs). Discovery of genes that interact with exposure to antibiotics can yield insights to drug targets and mechanisms of action or resistance. The premise is to look for CRISPRi mu...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418283/ https://www.ncbi.nlm.nih.gov/pubmed/37577548 http://dx.doi.org/10.1101/2023.08.03.551759 |