A dose-finding study to guide use of verapamil as an adjunctive therapy in tuberculosis

Induction of mycobacterial efflux pumps is a cause of Mycobacterium tuberculosis (Mtb) drug tolerance, a barrier to shortening antitubercular treatment. Verapamil inhibits Mtb efflux pumps that mediate tolerance to rifampin, a cornerstone of tuberculosis treatment. Verapamil’s mycobacterial efflux p...

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Detalles Bibliográficos
Autores principales: Padmapriyadarsini, Chandrasekaran, Szumowski, John D., Akbar, Nabila, Shanmugasundaram, Prema, Jain, Anilkumar, Bathragiri, Marasamy, Pattnaik, Manoranjan, Turuk, Jyotirmayee, Karunaianantham, Ramesh, Balakrishnan, Senthilkumar, Pati, Sangamitra, Agibothu Kupparam, Hemanth K., Rathore, Manoj Kumar, Raja, Jegadeesh, Naidu, K. Raghu, Horn, John, Whitworth, Laura, Sewell, Roger, Ramakrishnan, Lalita, Swaminathan, Soumya, Edelstein, Paul H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418293/
https://www.ncbi.nlm.nih.gov/pubmed/37577511
http://dx.doi.org/10.1101/2023.07.28.23293316

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418293/
https://www.ncbi.nlm.nih.gov/pubmed/37577511
http://dx.doi.org/10.1101/2023.07.28.23293316

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