Tetracyclic 1,4-Naphthoquinone Thioglucoside Conjugate U-556 Blocks the Purinergic P2X7 Receptor in Macrophages and Exhibits Anti-Inflammatory Activity In Vivo

P2X7 receptors (P2X7Rs) are ligand-gated ion channels that play a significant role in inflammation and are considered a potential therapeutic target for some inflammatory diseases. We have previously shown that a number of synthetic 1,4-naphthoquinones are capable of blocking P2X7Rs in neuronal and...

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Detalles Bibliográficos
Autores principales: Kozlovskiy, Sergei, Pislyagin, Evgeny, Menchinskaya, Ekaterina, Chingizova, Ekaterina, Kaluzhskiy, Leonid, Ivanov, Alexis S., Likhatskaya, Galina, Agafonova, Irina, Sabutski, Yuri, Polonik, Sergey, Manzhulo, Igor, Aminin, Dmitry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418395/
https://www.ncbi.nlm.nih.gov/pubmed/37569745
http://dx.doi.org/10.3390/ijms241512370

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418395/
https://www.ncbi.nlm.nih.gov/pubmed/37569745
http://dx.doi.org/10.3390/ijms241512370

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