Cargando…

Tetracyclic 1,4-Naphthoquinone Thioglucoside Conjugate U-556 Blocks the Purinergic P2X7 Receptor in Macrophages and Exhibits Anti-Inflammatory Activity In Vivo

P2X7 receptors (P2X7Rs) are ligand-gated ion channels that play a significant role in inflammation and are considered a potential therapeutic target for some inflammatory diseases. We have previously shown that a number of synthetic 1,4-naphthoquinones are capable of blocking P2X7Rs in neuronal and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kozlovskiy, Sergei, Pislyagin, Evgeny, Menchinskaya, Ekaterina, Chingizova, Ekaterina, Kaluzhskiy, Leonid, Ivanov, Alexis S., Likhatskaya, Galina, Agafonova, Irina, Sabutski, Yuri, Polonik, Sergey, Manzhulo, Igor, Aminin, Dmitry
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418395/ https://www.ncbi.nlm.nih.gov/pubmed/37569745 http://dx.doi.org/10.3390/ijms241512370

Ejemplares similares

Anti-Inflammatory Activity of 1,4-Naphthoquinones Blocking P2X7 Purinergic Receptors in RAW 264.7 Macrophage Cells
por: Kozlovskiy, Sergei A., et al.
Publicado: (2023)

Neuroprotective Effect of 1,4-Naphthoquinones in an In Vitro Model of Paraquat and 6-OHDA-Induced Neurotoxicity
por: Menchinskaya, Ekaterina, et al.
Publicado: (2021)

Synthesis, Cytotoxic Activity Evaluation and Quantitative Structure-ActivityAnalysis of Substituted 5,8-Dihydroxy-1,4-naphthoquinones and Their O- and S-Glycoside Derivatives Tested against Neuro-2a Cancer Cells
por: Polonik, Sergey, et al.
Publicado: (2020)

Synthesis and Evaluation of Antimicrobial and Cytotoxic Activity of Oxathiine-Fused Quinone-Thioglucoside Conjugates of Substituted 1,4-Naphthoquinones
por: Sabutski, Yuri E., et al.
Publicado: (2020)

Glycosides from edible sea cucumbers stimulate macrophages via purinergic receptors
por: Aminin, Dmitry, et al.
Publicado: (2016)

Lanostane Triterpenoid Metabolites from a Penares sp. Marine Sponge Protect Neuro-2a Cells against Paraquat Neurotoxicity
por: Yurchenko, Ekaterina A., et al.
Publicado: (2020)

Kunitz-Type Peptides from Sea Anemones Protect Neuronal Cells against Parkinson’s Disease Inductors via Inhibition of ROS Production and ATP-Induced P2X7 Receptor Activation
por: Kvetkina, Aleksandra, et al.
Publicado: (2022)

The Anti-Inflammatory Effect of Carrageenan/Echinochrom Complex at Experimental Endotoxemia
por: Yermak, Irina M., et al.
Publicado: (2022)

Recombinant Analogs of Sea Anemone Kunitz-Type Peptides Influence P2X7 Receptor Activity in Neuro-2a Cells
por: Pislyagin, Evgeny A., et al.
Publicado: (2023)

Cytoprotective Activity of p-Terphenyl Polyketides and Flavuside B from Marine-Derived Fungi against Oxidative Stress in Neuro-2a Cells
por: Yurchenko, Ekaterina A., et al.
Publicado: (2021)

Phytoceramides from the Marine Sponge Monanchora clathrata: Structural Analysis and Cytoprotective Effects
por: Santalova, Elena A., et al.
Publicado: (2023)

A new multigene HCIQ subfamily from the sea anemone Heteractis crispa encodes Kunitz-peptides exhibiting neuroprotective activity against 6-hydroxydopamine
por: Kvetkina, Aleksandra, et al.
Publicado: (2020)

Marine Fungal Cerebroside Flavuside B Protects HaCaT Keratinocytes against Staphylococcus aureus Induced Damage
por: Chingizova, Ekaterina A., et al.
Publicado: (2021)

Holothurian triterpene glycoside cucumarioside A(2)-2 induces macrophages activation and polarization in cancer immunotherapy
por: Chuang, Wen-Han, et al.
Publicado: (2023)

Purinergic Signaling in Neuroinflammation
por: Aminin, Dmitry, et al.
Publicado: (2021)

Sea Anemone Kunitz-Type Peptides Demonstrate Neuroprotective Activity in the 6-Hydroxydopamine Induced Neurotoxicity Model
por: Sintsova, Oksana, et al.
Publicado: (2021)

Polyphenolic Compounds from Lespedeza bicolor Protect Neuronal Cells from Oxidative Stress
por: Tarbeeva, Darya V., et al.
Publicado: (2022)

Modulation of Doxorubicin Intracellular Accumulation and Anticancer Activity by Triterpene Glycoside Cucumarioside A(2)-2
por: Menchinskaya, Ekaterina, et al.
Publicado: (2019)

Neuroprotective Metabolites from Vietnamese Marine Derived Fungi of Aspergillus and Penicillium Genera
por: Girich, Elena V., et al.
Publicado: (2020)

Anticancer Activity of Sea Cucumber Triterpene Glycosides
por: Aminin, Dmitry L., et al.
Publicado: (2015)

Cucumarioside A(2)-2 Causes Macrophage Activation in Mouse Spleen
por: Pislyagin, Evgeny A., et al.
Publicado: (2017)

Neuroprotective Activity of Some Marine Fungal Metabolites in the 6-Hydroxydopamin- and Paraquat-Induced Parkinson’s Disease Models
por: Yurchenko, Ekaterina A., et al.
Publicado: (2018)

Formation of thioglucoside single crystals by coherent molecular vibrational excitation using a 10-fs laser pulse
por: Iwakura, Izumi, et al.
Publicado: (2020)

Biologically Active Echinulin-Related Indolediketopiperazines from the Marine Sediment-Derived Fungus Aspergillus niveoglaucus
por: Smetanina, Olga F., et al.
Publicado: (2019)

Virescenosides from the Holothurian-Associated Fungus Acremonium striatisporum Kmm 4401
por: Zhuravleva, Olesya I., et al.
Publicado: (2019)

Neuroprotective and Antiherpetic Properties of Polyphenolic Compounds from Maackia amurensis Heartwood
por: Tarbeeva, Darya V., et al.
Publicado: (2023)

New Anti-Hypoxic Metabolites from Co-Culture of Marine-Derived Fungi Aspergillus carneus KMM 4638 and Amphichorda sp. KMM 4639
por: Belousova, Elena B., et al.
Publicado: (2023)

Tetracyclic Antidepressant Causing Altered Biodistribution of MIBG
por: Goel, Sumina R., et al.
Publicado: (2015)

A modular synthesis of tetracyclic meroterpenoid antibiotics
por: Wildermuth, Raphael, et al.
Publicado: (2017)

Advancements in the synthesis of fused tetracyclic quinoline derivatives
por: Mekheimer, Ramadan A., et al.
Publicado: (2020)

Divergent Strategy in Marine Tetracyclic Meroterpenoids Synthesis
por: Rosales Martínez, Antonio, et al.
Publicado: (2021)

49 easy electronic projects for the 556 dual timer /
por: Horn, Delton T.
Publicado: (1991)

SUN-556 Cardiac Phenotype in Familial Partial Lipodystrophy
por: Eldin, Abdelwahab Jalal, et al.
Publicado: (2020)

Inspired by Sea Urchins: Warburg Effect Mediated Selectivity of Novel Synthetic Non-Glycoside 1,4-Naphthoquinone-6S-Glucose Conjugates in Prostate Cancer
por: Dyshlovoy, Sergey A., et al.
Publicado: (2020)

N-docosahexaenoylethanolamine reduces neuroinflammation and cognitive impairment after mild traumatic brain injury in rats
por: Ponomarenko, Arina I., et al.
Publicado: (2021)

Microfluidic light-driven synthesis of tetracyclic molecular architectures
por: Mateos, Javier, et al.
Publicado: (2018)

Tetracyclic Thioxanthene Derivatives: Studies on Fluorescence and Antitumor Activity
por: Durães, Fernando, et al.
Publicado: (2021)

Biomimetic approach to the catalytic enantioselective synthesis of tetracyclic isochroman
por: Lin, Xiangfeng, et al.
Publicado: (2021)

SUN-556 A Case of Fatal Amiodarone Induced Thyrotoxicosis
por: Patel, Sabah, et al.
Publicado: (2019)

Antiviral Potential of Sea Urchin Aminated Spinochromes against Herpes Simplex Virus Type 1
por: Mishchenko, Natalia P., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_vipfi5hdqod2m81j7gr0uk4fmt