Cytokine Inhibitors Upregulate Extracellular Matrix Anabolism of Human Intervertebral Discs under Alginate Beads and Alginate-Embedded Explant Cultures

We investigated the effects of the cytokine inhibitors IL-1 receptor antagonist (IL-1Ra) and soluble tumor necrosis factor receptor-1 (sTNFR1) on the extracellular matrix metabolism of human intervertebral discs (IVDs) and the roles of IL-1β and TNF in the homeostasis of IVD cells. The 1.2% alginate...

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Detalles Bibliográficos
Autores principales: Kakutani, Kenichiro, Yurube, Takashi, An, Howard S., Doita, Minoru, Masuda, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418414/
https://www.ncbi.nlm.nih.gov/pubmed/37569715
http://dx.doi.org/10.3390/ijms241512336

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418414/
https://www.ncbi.nlm.nih.gov/pubmed/37569715
http://dx.doi.org/10.3390/ijms241512336

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