Aging Model for Analyzing Drug-Induced Proarrhythmia Risks Using Cardiomyocytes Differentiated from Progeria-Patient-Derived Induced Pluripotent Stem Cells

Among various cardiac safety concerns, proarrhythmia risks, including QT prolongation leading to Torsade de Pointes, is one of major cause for drugs being withdrawn (~45% 1975–2007). Preclinical study requires the evaluation of proarrhythmia using in silico, in vitro, and/or animal models. Consideri...

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Detalles Bibliográficos
Autores principales: Daily, Neil, Elson, Julian, Wakatsuki, Tetsuro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418415/
https://www.ncbi.nlm.nih.gov/pubmed/37569335
http://dx.doi.org/10.3390/ijms241511959

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418415/
https://www.ncbi.nlm.nih.gov/pubmed/37569335
http://dx.doi.org/10.3390/ijms241511959

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