Composites of N-butyl-N-methyl-1-phenylpyrrolo[1,2-a]pyrazine-3-carboxamide with Polymers: Effect of Crystallinity on Solubility and Stability

This work aimed to develop and characterize a water-soluble, high-release active pharmaceutical ingredient (API) composite based on the practically water-insoluble API N-butyl-N-methyl-1-phenylpyrrolo[1,2-a]pyrazine-3-carboxamide (GML-3), a substance with antidepressant and anxiolytic action. This a...

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Detalles Bibliográficos
Autores principales: Markeev, Vladimir B., Blynskaya, Evgenia V., Tishkov, Sergey V., Alekseev, Konstantin V., Marakhova, Anna I., Vetcher, Alexandre A., Shishonin, Alexander Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418436/
https://www.ncbi.nlm.nih.gov/pubmed/37569589
http://dx.doi.org/10.3390/ijms241512215

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418436/
https://www.ncbi.nlm.nih.gov/pubmed/37569589
http://dx.doi.org/10.3390/ijms241512215

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