Cue to Acid-Induced Long-Range Conformational Changes in an Antibody Preceding Aggregation: The Structural Origins of the Subpeaks in Kratky Plots of Small-Angle X-ray Scattering

Antibody aggregation, followed by acid denaturation and neutralization of pH, is one of the reasons why the production of therapeutic monoclonal antibodies (mAbs) is expensive. Determining the structural details of acid-denatured antibodies is important for understanding their aggregation mechanism...

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Detalles Bibliográficos
Autores principales: Imamura, Hiroshi, Honda, Shinya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418478/
https://www.ncbi.nlm.nih.gov/pubmed/37569415
http://dx.doi.org/10.3390/ijms241512042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418478/
https://www.ncbi.nlm.nih.gov/pubmed/37569415
http://dx.doi.org/10.3390/ijms241512042

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