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NMR-Chemical-Shift-Driven Protocol Reveals the Cofactor-Bound, Complete Structure of Dynamic Intermediates of the Catalytic Cycle of Oncogenic KRAS G12C Protein and the Significance of the Mg(2+) Ion
In this work, catalytically significant states of the oncogenic G12C variant of KRAS, those of Mg(2+)-free and Mg(2+)-bound GDP-loaded forms, have been determined using CS-Rosetta software and NMR-data-driven molecular dynamics simulations. There are several Mg(2+)-bound G12C KRAS/GDP structures dep...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418480/ https://www.ncbi.nlm.nih.gov/pubmed/37569478 http://dx.doi.org/10.3390/ijms241512101 |