Whole Transcriptome Analysis of Substantia Nigra in Mice with MPTP-Induced Parkinsonism Bearing Defective Glucocerebrosidase Activity

Mutations in the GBA1 gene represent the major genetic risk factor for Parkinson’s disease (PD). The lysosomal enzyme beta-glucocerebrosidase (GCase) encoded by the GBA1 gene participates in both the endolysosomal pathway and the immune response. Disruption of these mechanisms is involved in PD path...

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Detalles Bibliográficos
Autores principales: Usenko, Tatiana, Bezrukova, Anastasia, Rudenok, Margarita M., Basharova, Katerina, Shadrina, Maria I., Slominsky, Petr A., Zakharova, Ekaterina, Pchelina, Sofya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418497/
https://www.ncbi.nlm.nih.gov/pubmed/37569538
http://dx.doi.org/10.3390/ijms241512164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418497/
https://www.ncbi.nlm.nih.gov/pubmed/37569538
http://dx.doi.org/10.3390/ijms241512164

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