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Cell autonomous role of border associated macrophages in ApoE4 neurovascular dysfunction and susceptibility to white matter injury

Apolipoprotein-E4 (ApoE4), the strongest genetic risk factor for sporadic Alzheimer’s disease, is also a risk factor for microvascular pathologies leading to cognitive impairment, particularly subcortical white matter injury. These effects have been attributed to alterations in the regulation of the...

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Detalles Bibliográficos
Autores principales: Iadecola, Costantino, Anfray, Antoine, Schaeffer, Samantha, Hattori, Yorito, Santisteban, Monica, Casey, Nicole, Wang, Gang, Strickland, Michael, Zhou, Ping, Holtzman, David, Anrather, Josef, Park, Laibaik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418550/
https://www.ncbi.nlm.nih.gov/pubmed/37577565
http://dx.doi.org/10.21203/rs.3.rs-3222611/v1