Cargando…

Design, Synthesis, and Biological Evaluation of New Potential Unusual Modified Anticancer Immunomodulators for Possible Non-Teratogenic Quinazoline-Based Thalidomide Analogs

Sixteen new thalidomide analogs were synthesized. The new candidates showed potent in vitro antiproliferative activities against three human cancer cell lines, namely hepatocellular carcinoma (HepG-2), prostate cancer (PC3), and breast cancer (MCF-7). It was found that compounds XII, XIIIa, XIIIb, X...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mabrouk, Reda R., Abdallah, Abdallah E., Mahdy, Hazem A., El-Kalyoubi, Samar A., Kamal, Omar Jamal, Abdelghany, Tamer M., Zayed, Mohamed F., Alshaeri, Heba K., Alasmari, Moudi M., El-Zahabi, Mohamed Ayman
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418715/ https://www.ncbi.nlm.nih.gov/pubmed/37569792 http://dx.doi.org/10.3390/ijms241512416

Ejemplares similares

Design, Synthesis, Molecular Modeling and Anti-Hyperglycemic Evaluation of Quinazoline-Sulfonylurea Hybrids as Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) and Sulfonylurea Receptor (SUR) Agonists
por: El-Zahabi, Mohamed Ayman, et al.
Publicado: (2022)

Design, synthesis, anticancer evaluation, and in silico ADMET analysis of novel thalidomide analogs as promising immunomodulatory agents
por: Kotb, Anas Ramadan, et al.
Publicado: (2023)

Design, synthesis, and biological evaluation of novel bioactive thalidomide analogs as anticancer immunomodulatory agents
por: Kotb, Anas Ramadan, et al.
Publicado: (2022)

Molecular Mechanisms of the Teratogenic Effects of Thalidomide
por: Asatsuma-Okumura, Tomoko, et al.
Publicado: (2020)

Nitric oxide rescues thalidomide mediated teratogenicity
por: Siamwala, Jamila H., et al.
Publicado: (2012)

Effects of Annona muricata Extract on Triple-Negative Breast Cancer Cells Mediated Through EGFR Signaling
por: Alshaeri, Heba K, et al.
Publicado: (2020)

Thalidomide and its metabolite 5‐hydroxythalidomide induce teratogenicity via the cereblon neosubstrate PLZF
por: Yamanaka, Satoshi, et al.
Publicado: (2021)

The Prevalence of Anxiety Among Children in Saudi Arabia During the COVID-19 Pandemic: A Cross-Sectional Study
por: Alasmari, Moudi M, et al.
Publicado: (2023)

Esco2 and cohesin regulate CRL4 ubiquitin ligase ddb1 expression and thalidomide teratogenicity
por: Sanchez, Annie C., et al.
Publicado: (2022)

Augmentation of Pectoral Fin Teratogenicity by Thalidomide in Human Cytochrome P450 3A-Expressing Zebrafish
por: Dong, Wenjing, et al.
Publicado: (2023)

Embryotoxic and Teratogenic Effects of Norfloxacin in Pregnant Female Albino Rats
por: Aboubakr, Mohamed, et al.
Publicado: (2014)

Synthesis, biological evaluation, and molecular docking of new series of antitumor and apoptosis inducers designed as VEGFR-2 inhibitors
por: Abdallah, Abdallah E., et al.
Publicado: (2022)

Embryotoxic and Teratogenic Effects of Tartrazine in Rats
por: Hashem, Mohamed Mohammed, et al.
Publicado: (2019)

Synthesis and anticancer activity of new quinazoline derivatives
por: Abuelizz, Hatem A., et al.
Publicado: (2017)

Medical students’ attitudes toward sleeping pill usage: A cross-sectional study
por: Alasmari, Moudi M., et al.
Publicado: (2022)

Design, synthesis, in silico studies, and biological evaluation of novel pyrimidine-5-carbonitrile derivatives as potential anti-proliferative agents, VEGFR-2 inhibitors and apoptotic inducers
por: Saleh, Abdulrahman M., et al.
Publicado: (2023)

The Immunomodulating Effects of Thalidomide and Dexamethasone in a Murine Cardiac Allograft Transplantation Model
por: Kim, Soo Jin, et al.
Publicado: (2022)

Synthesis and anticancer evaluation of some novel pyrimido[5,4-e][1,2,4]triazines and pyrazolo[3,4-d]pyrimidine using DMF-DMA as methylating and cyclizing agent
por: El-Kalyoubi, Samar A.
Publicado: (2018)

Diagnostic efficacy of cystatin-c in association with different ACE genes predicting renal insufficiency in T2DM
por: Taha, Mona Mohamed, et al.
Publicado: (2023)

Potential Use of Thalidomide in Glioblastoma Treatment: An Updated Brief Overview
por: Eatmann, Ahmed Ismail, et al.
Publicado: (2023)

A Novel Synthesis of Fused Uracils: Indenopyrimidopyridazines, Pyrimidopyridazines, and Pyrazolopyrimidines for Antimicrobial and Antitumor Evalution
por: El-Kalyoubi, Samar, et al.
Publicado: (2016)

Synthesis, In Silico Prediction and In Vitro Evaluation of Antitumor Activities of Novel Pyrido[2,3-d]pyrimidine, Xanthine and Lumazine Derivatives
por: El-Kalyoubi, Samar, et al.
Publicado: (2020)

Molecular docking study and antiviral evaluation of 2-thioxo-benzo[g]quinazolin-4(3H)-one derivatives
por: Al-Salahi, Rashad, et al.
Publicado: (2016)

Teratogenicity and hyperprolactinemia
por: Andrade, Chittaranjan
Publicado: (2009)

Teratogenicity with Olanzapine
por: Prakash, Sathya, et al.
Publicado: (2014)

Correction: El-kalyoubi, S.; et al. Novel 2-Thioxanthine and Dipyrimidopyridine Derivatives: Synthesis and Antimicrobial Activity. Molecules, 2015, 20, 19263--19276
por: El-kalyoubi, Samar, et al.
Publicado: (2018)

Novel 2-Thioxanthine and Dipyrimidopyridine Derivatives: Synthesis and Antimicrobial Activity †
por: El-kalyoubi, Samar, et al.
Publicado: (2015)

The teratogenic effects of imatinib mesylate on rat fetuses
por: El Gendy, M.M., et al.
Publicado: (2015)

Carbonic Anhydrase Inhibition Activities of Schiff’s Bases Based on Quinazoline-Linked Benzenesulfonamide
por: El-Azab, Adel S., et al.
Publicado: (2022)

The Effect of Encapsulated Apigenin Nanoparticles on HePG-2 Cells through Regulation of P53
por: Mabrouk Zayed, Mayada Mohamed, et al.
Publicado: (2022)

Molecular Docking and Anticonvulsant Activity of Newly Synthesized Quinazoline Derivatives
por: Abuelizz, Hatem A., et al.
Publicado: (2017)

Catalog of Teratogenic Agents
por: Craig, A. W.
Publicado: (1974)

Catalog of Teratogenic Agents
por: Craig, A. W.
Publicado: (1980)

Catalog of Teratogenic Agents
por: Craig, A. W.
Publicado: (1977)

Teratogenicity of Antiepileptic Drugs
por: Güveli, Betül Tekin, et al.
Publicado: (2017)

Teratogenicity and Antiseizure Medications
por: Meador, Kimford
Publicado: (2020)

Teratogenicity of D-allulose
por: Sa, Soonok, et al.
Publicado: (2022)

Synthesis, Modelling, and Anticonvulsant Studies of New Quinazolines Showing Three Highly Active Compounds with Low Toxicity and High Affinity to the GABA-A Receptor
por: Zayed, Mohamed F., et al.
Publicado: (2017)

Natural Immunomodulators Treat the Cytokine Storm in SARS-CoV-2
por: Abbas, Heba Salah, et al.
Publicado: (2023)

New [1,2,4]triazolo[4,3-c]quinazolines as intercalative Topo II inhibitors: Design, synthesis, biological evaluation, and in silico studies
por: Gaber, Ahmed A., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_lleph4b7rmfccb8osa2iq95c1n