Cargando…

Lipophilic Studies and In Silico ADME Profiling of Biologically Active 2-Aminothiazol-4(5H)-one Derivatives

Pseudothiohydantoin derivatives have a wide range of biological activities and are widely used in the development of new pharmaceuticals. Lipophilicity is a basic, but very important parameter in the design of potential drugs, as it determines solubility in lipids, nonpolar solvents, and makes it po...

Descripción completa

Detalles Bibliográficos
Autores principales:	Redka, Małgorzata, Baumgart, Szymon, Kupczyk, Daria, Kosmalski, Tomasz, Studzińska, Renata
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418735/ https://www.ncbi.nlm.nih.gov/pubmed/37569606 http://dx.doi.org/10.3390/ijms241512230

Ejemplares similares

A Review of Biologically Active Oxime Ethers
por: Kosmalski, Tomasz, et al.
Publicado: (2023)

The Oxime Ethers with Heterocyclic, Alicyclic and Aromatic Moiety as Potential Anti-Cancer Agents
por: Kosmalski, Tomasz, et al.
Publicado: (2022)

A Novel N-Tert-Butyl Derivatives of Pseudothiohydantoin as Potential Target in Anti-Cancer Therapy
por: Kupczyk, Daria, et al.
Publicado: (2021)

Synthesis of Novel 2-(Isopropylamino)thiazol-4(5H)-one Derivatives and Their Inhibitory Activity of 11β-HSD1 and 11β-HSD2 in Aspect of Carcinogenesis Prevention
por: Kupczyk, Daria, et al.
Publicado: (2020)

Novel 2-(Adamantan-1-ylamino)Thiazol-4(5H)-One Derivatives and Their Inhibitory Activity towards 11β-HSD1—Synthesis, Molecular Docking and In Vitro Studies
por: Studzińska, Renata, et al.
Publicado: (2021)

Synthesis of Novel 2-(Cyclopentylamino)thiazol-4(5H)-one Derivatives with Potential Anticancer, Antioxidant, and 11β-HSD Inhibitory Activities
por: Baumgart, Szymon, et al.
Publicado: (2023)

11β-Hydroxysteroid Dehydrogenase Type 1 as a Potential Treatment Target in Cardiovascular Diseases
por: Kupczyk, Daria, et al.
Publicado: (2022)

A Review of the Biological Activity of Amidrazone Derivatives
por: Paprocka, Renata, et al.
Publicado: (2022)

Study of Lipophilicity and ADME Properties of 1,9-Diazaphenothiazines with Anticancer Action
por: Morak-Młodawska, Beata, et al.
Publicado: (2023)

11β-HSD as a New Target in Pharmacotherapy of Metabolic Diseases
por: Kupczyk, Daria, et al.
Publicado: (2022)

Application of ELISA Technique and Human Microsomes in the Search for 11β-Hydroxysteroid Dehydrogenase Inhibitors
por: Kupczyk, Daria, et al.
Publicado: (2019)

Assessment of the concentration of selected metalloproteinases (MMP-2, MMP-3, MMP-9 and MMP-13) in patients with ulcers as a complication of type 2 diabetes
por: Kupczyk, Daria, et al.
Publicado: (2020)

Diversity of the Chemical Profile and Biological Activity of Capsicum annuum L. Extracts in Relation to Their Lipophilicity
por: Chilczuk, Barbara, et al.
Publicado: (2021)

An Overview on Synthetic 2-Aminothiazole-Based Compounds Associated with Four Biological Activities
por: Farouk Elsadek, Mohamed, et al.
Publicado: (2021)

In Silico ADME/Tox Profiling of Natural Products: A Focus on BIOFACQUIM
por: Durán-Iturbide, Noemi Angeles, et al.
Publicado: (2020)

Concentration of proinflammatory cytokines in patients with ulcers as a complication of type 2 diabetes mellitus
por: Kupczyk, Daria, et al.
Publicado: (2020)

In silico ADME and Toxicity Prediction of Ceftazidime and Its Impurities
por: Han, Ying, et al.
Publicado: (2019)

Study of the Room‐Temperature Synthesis of Oxime Ethers by using a Super Base
por: Kosmalski, Tomasz, et al.
Publicado: (2018)

One-pot synthesis, computational chemical study, molecular docking, biological study, and in silico prediction ADME/pharmacokinetics properties of 5-substituted 1H-tetrazole derivatives
por: El-Sewedy, Ahmed, et al.
Publicado: (2023)

One-Pot Multicomponent Synthesis of Methoxybenzo[h]quinoline-3-carbonitrile Derivatives; Anti-Chagas, X-ray, and In Silico ADME/Tox Profiling Studies
por: Ramírez, Hegira, et al.
Publicado: (2021)

Synthesis and antifungal activity of benzimidazole, benzotriazole and aminothiazole derivatives
por: Khabnadideh, S., et al.
Publicado: (2012)

Synthesis and Evaluation of the 2-Aminothiazoles as Anti-Tubercular Agents
por: Kesicki, Edward A., et al.
Publicado: (2016)

Identification of Enolase as the Target of 2-Aminothiazoles in Mycobacterium tuberculosis
por: Wescott, Heather H., et al.
Publicado: (2018)

QSAR study of anti-prion activity of 2-aminothiazoles
por: Mandi, Prasit, et al.
Publicado: (2012)

In Silico ADME, Metabolism Prediction and Hydrolysis Study of Melatonin Derivatives
por: Panyatip, Panyada, et al.
Publicado: (2020)

Antitrypanosomal activity of 5-nitro-2-aminothiazole-based compounds
por: Papadopoulou, Maria V., et al.
Publicado: (2016)

Synthesis and Evaluation of Aminothiazole-Paeonol Derivatives as Potential Anticancer Agents
por: Tsai, Chia-Ying, et al.
Publicado: (2016)

Improving Antimicrobial Activity and Physico-Chemical Properties by Isosteric Replacement of 2-Aminothiazole with 2-Aminooxazole
por: Juhás, Martin, et al.
Publicado: (2022)

Prediction of In-silico ADME Properties of 1,2-O-Isopropylidene Aldohexose Derivatives
por: Kovačević, Strahinja Z, et al.
Publicado: (2014)

Bis(2-aminothiazole-4-acetato)aquazinc(II)
por: Zhang, Lai-Jun, et al.
Publicado: (2009)

Development and therapeutic potential of 2-aminothiazole derivatives in anticancer drug discovery
por: Alizadeh, Seyedeh Roya, et al.
Publicado: (2021)

Synthesis of Novel Aminothiazole Derivatives as Promising Antiviral, Antioxidant and Antibacterial Candidates
por: Minickaitė, Rūta, et al.
Publicado: (2022)

In silico evaluation of binding interaction and ADME study of new 1,3-diazetidin-2-one derivatives with high antiproliferative activity
por: Abdulredha, Farah Haidar, et al.
Publicado: (2023)

Lipophilic Micronutrients and Adipose Tissue Biology
por: Landrier, Jean-François, et al.
Publicado: (2012)

Design, Synthesis, Molecular Docking, and Evaluation Antioxidant and Antimicrobial Activities for Novel 3-phenylimidazolidin-4-one and 2-aminothiazol-4-one Derivatives
por: Shehab, Wesam S., et al.
Publicado: (2022)

Thiazole–Chalcone Hybrids as Prospective Antitubercular and Antiproliferative Agents: Design, Synthesis, Biological, Molecular Docking Studies and In Silico ADME Evaluation
por: Kasetti, Ashok Babu, et al.
Publicado: (2021)

The Trends and Future Prospective of In Silico Models from the Viewpoint of ADME Evaluation in Drug Discovery
por: Komura, Hiroshi, et al.
Publicado: (2023)

A one-pot electrochemical synthesis of 2-aminothiazoles from active methylene ketones and thioureas mediated by NH(4)I
por: Yang, Shang-Feng, et al.
Publicado: (2022)

In Vitro and In Silico ADME-Tox Profiling and Safety Significance of Multifunctional Monoamine Oxidase Inhibitors Targeting Neurodegenerative Diseases
por: Więckowska, Anna, et al.
Publicado: (2020)

Design, synthesis, biological assessment and in silico ADME prediction of new 2-(4-(methylsulfonyl) phenyl) benzimidazoles as selective cyclooxygenase-2 inhibitors
por: Badawy, Mohamed A. S., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_i6g5pruvi1qmu31j49ukrv8dsa