Nuclear Expression of TDP-43 Is Linked with Morphology and Ubiquitylation of Cytoplasmic Aggregates in Amyotrophic Lateral Sclerosis

The transactive response DNA-binding protein of 43 kDa (TDP-43) is a pathological protein of amyotrophic lateral sclerosis (ALS). TDP-43 pathology is characterized by a combination of the cytoplasmic aggregation and nuclear clearance of this protein. However, the mechanisms underlying TDP-43 patholo...

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Detalles Bibliográficos
Autores principales: Yabata, Hiroyuki, Riku, Yuichi, Miyahara, Hiroaki, Akagi, Akio, Sone, Jun, Urushitani, Makoto, Yoshida, Mari, Iwasaki, Yasushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418808/
https://www.ncbi.nlm.nih.gov/pubmed/37569549
http://dx.doi.org/10.3390/ijms241512176

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418808/
https://www.ncbi.nlm.nih.gov/pubmed/37569549
http://dx.doi.org/10.3390/ijms241512176

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