Cargando…

Nuclear Expression of TDP-43 Is Linked with Morphology and Ubiquitylation of Cytoplasmic Aggregates in Amyotrophic Lateral Sclerosis

The transactive response DNA-binding protein of 43 kDa (TDP-43) is a pathological protein of amyotrophic lateral sclerosis (ALS). TDP-43 pathology is characterized by a combination of the cytoplasmic aggregation and nuclear clearance of this protein. However, the mechanisms underlying TDP-43 patholo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yabata, Hiroyuki, Riku, Yuichi, Miyahara, Hiroaki, Akagi, Akio, Sone, Jun, Urushitani, Makoto, Yoshida, Mari, Iwasaki, Yasushi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418808/ https://www.ncbi.nlm.nih.gov/pubmed/37569549 http://dx.doi.org/10.3390/ijms241512176

Ejemplares similares

TDP-43 Proteinopathy and Tauopathy: Do They Have Pathomechanistic Links?
por: Riku, Yuichi, et al.
Publicado: (2022)

Pathway from TDP-43-Related Pathology to Neuronal Dysfunction in Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration
por: Riku, Yuichi, et al.
Publicado: (2021)

Independent distribution between tauopathy secondary to subacute sclerotic panencephalitis and measles virus: An immunohistochemical analysis in autopsy cases including cases treated with aggressive antiviral therapies
por: Miyahara, Hiroaki, et al.
Publicado: (2022)

DCTN1 Binds to TDP-43 and Regulates TDP-43 Aggregation
por: Deshimaru, Manami, et al.
Publicado: (2021)

Suppression of Linear Ubiquitination Ameliorates Cytoplasmic Aggregation of Truncated TDP-43
por: Zhang, Qiang, et al.
Publicado: (2022)

Phosphorylated TDP-43 (pTDP-43) aggregates in the axial skeletal muscle of patients with sporadic and familial amyotrophic lateral sclerosis
por: Cykowski, Matthew D., et al.
Publicado: (2018)

Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-43
por: Uchida, Azusa, et al.
Publicado: (2012)

NOTCH2NLC GGC repeat expansion causes retinal pathology with intranuclear inclusions throughout the retina and causes visual impairment
por: Sone, Jun, et al.
Publicado: (2023)

Cytoplasmic Accumulation and Aggregation of TDP-43 upon Proteasome Inhibition in Cultured Neurons
por: van Eersel, Janet, et al.
Publicado: (2011)

Stress Granule Assembly Can Facilitate but Is Not Required for TDP-43 Cytoplasmic Aggregation
por: Fernandes, Nikita, et al.
Publicado: (2020)

Cytoplasmic TDP43 Binds microRNAs: New Disease Targets in Amyotrophic Lateral Sclerosis
por: Paez-Colasante, Ximena, et al.
Publicado: (2020)

Phosphorylated TDP-43 aggregates in peripheral motor nerves of patients with amyotrophic lateral sclerosis
por: Riva, Nilo, et al.
Publicado: (2022)

Mass spectrometric analysis of accumulated TDP-43 in amyotrophic lateral sclerosis brains
por: Kametani, Fuyuki, et al.
Publicado: (2016)

A C-Terminally Truncated TDP-43 Splice Isoform Exhibits Neuronal Specific Cytoplasmic Aggregation and Contributes to TDP-43 Pathology in ALS
por: Shenouda, Marc, et al.
Publicado: (2022)

Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation
por: Gruijs da Silva, Lara A, et al.
Publicado: (2022)

System degeneration in an MM1-type sporadic Creutzfeldt-Jakob disease case with an unusually prolonged akinetic mutism state
por: Iwasaki, Yasushi, et al.
Publicado: (2021)

Molecular Dissection of TDP-43 as a Leading Cause of ALS/FTLD
por: Tamaki, Yoshitaka, et al.
Publicado: (2022)

Spinal cord extracts of amyotrophic lateral sclerosis spread TDP-43 pathology in cerebral organoids
por: Tamaki, Yoshitaka, et al.
Publicado: (2023)

TDP-43 and Phosphorylated TDP-43 Levels in Paired Plasma and CSF Samples in Amyotrophic Lateral Sclerosis
por: Ren, Yuting, et al.
Publicado: (2021)

Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis
por: Oiwa, Kotaro, et al.
Publicado: (2023)

The debated toxic role of aggregated TDP-43 in amyotrophic lateral sclerosis: a resolution in sight?
por: Hergesheimer, Rudolf C, et al.
Publicado: (2019)

Chaperone Mediated Autophagy Degrades TDP-43 Protein and Is Affected by TDP-43 Aggregation
por: Ormeño, Fernando, et al.
Publicado: (2020)

Old age amyotrophic lateral sclerosis and limbic TDP‐43 pathology
por: Murakami, Aya, et al.
Publicado: (2022)

p62 overexpression induces TDP-43 cytoplasmic mislocalisation, aggregation and cleavage and neuronal death
por: Foster, A. D., et al.
Publicado: (2021)

TDP-43—The key to understanding amyotrophic lateral sclerosis
por: Xu, Zuoshang, et al.
Publicado: (2014)

The role of TDP-43 mislocalization in amyotrophic lateral sclerosis
por: Suk, Terry R., et al.
Publicado: (2020)

Elimination of TDP-43 inclusions linked to amyotrophic lateral sclerosis by a misfolding-specific intrabody with dual proteolytic signals
por: Tamaki, Yoshitaka, et al.
Publicado: (2018)

The cooperative binding of TDP-43 to GU-rich RNA repeats antagonizes TDP-43 aggregation
por: Rengifo-Gonzalez, Juan Carlos, et al.
Publicado: (2021)

Aggregation-prone TDP-43 sequesters and drives pathological transitions of free nuclear TDP-43
por: Keating, Sean S., et al.
Publicado: (2023)

Praja1 RING‐finger E3 ubiquitin ligase suppresses neuronal cytoplasmic TDP‐43 aggregate formation
por: Watabe, Kazuhiko, et al.
Publicado: (2020)

Inflammation Induces TDP-43 Mislocalization and Aggregation
por: Correia, Ana Sofia, et al.
Publicado: (2015)

Which TDP-43 aggregates are toxic in ALS?
por: Valle, Cristiana, et al.
Publicado: (2016)

Phosphorylated TDP-43 aggregates in skeletal and cardiac muscle are a marker of myogenic degeneration in amyotrophic lateral sclerosis and various conditions
por: Mori, Fumiaki, et al.
Publicado: (2019)

TDP-43 protein variants as biomarkers in amyotrophic lateral sclerosis
por: Williams, Stephanie M., et al.
Publicado: (2017)

Clinical Significance of TDP-43 Neuropathology in Amyotrophic Lateral Sclerosis
por: Cykowski, Matthew D., et al.
Publicado: (2017)

TDP‐43 as structure‐based biomarker in amyotrophic lateral sclerosis
por: Beyer, Léon, et al.
Publicado: (2020)

Intracellular Conformation of Amyotrophic Lateral Sclerosis-Causative TDP-43
por: Kitamura, Akira, et al.
Publicado: (2023)

Integrated Omic Analysis Delineates Pathways Modulating Toxic TDP-43 Protein Aggregates in Amyotrophic Lateral Sclerosis
por: Rajaratnam, Saiswaroop, et al.
Publicado: (2023)

Antibody against TDP-43 phosphorylated at serine 375 suggests conformational differences of TDP-43 aggregates among FTLD–TDP subtypes
por: Neumann, Manuela, et al.
Publicado: (2020)

TDP-43 Cytoplasmic Translocation in the Skin Fibroblasts of ALS Patients
por: Rubio, Miguel A., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_qlakks9l3r19n23lhcqv8ph598