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Nuclear Expression of TDP-43 Is Linked with Morphology and Ubiquitylation of Cytoplasmic Aggregates in Amyotrophic Lateral Sclerosis

The transactive response DNA-binding protein of 43 kDa (TDP-43) is a pathological protein of amyotrophic lateral sclerosis (ALS). TDP-43 pathology is characterized by a combination of the cytoplasmic aggregation and nuclear clearance of this protein. However, the mechanisms underlying TDP-43 patholo...

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Detalles Bibliográficos
Autores principales:	Yabata, Hiroyuki, Riku, Yuichi, Miyahara, Hiroaki, Akagi, Akio, Sone, Jun, Urushitani, Makoto, Yoshida, Mari, Iwasaki, Yasushi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418808/ https://www.ncbi.nlm.nih.gov/pubmed/37569549 http://dx.doi.org/10.3390/ijms241512176

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