Synthesis, (123)I-Radiolabeling Optimization, and Initial Preclinical Evaluation of Novel Urea-Based PSMA Inhibitors with a Tributylstannyl Prosthetic Group in Their Structures

Prostate-specific membrane antigen (PSMA) has been identified as a target for the development of theranostic agents. In our current work, we describe the design and synthesis of novel N-[N-[(S)-1,3-dicarboxypropyl]carbamoyl]-(S)-L-lysine (DCL) urea-based PSMA inhibitors with a chlorine-substituted a...

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Detalles Bibliográficos
Autores principales: Hasnowo, Lutfi A., Larkina, Maria S., Plotnikov, Evgenii, Bodenko, Vitalina, Yuldasheva, Feruza, Stasyuk, Elena, Petrov, Stanislav A., Zyk, Nikolai Y., Machulkin, Aleksei E., Vorozhtsov, Nikolai I., Beloglazkina, Elena K., Nenajdenko, Valentine G., Tolmachev, Vladimir, Orlova, Anna, Majouga, Alexander G., Yusubov, Mekhman S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418939/
https://www.ncbi.nlm.nih.gov/pubmed/37569582
http://dx.doi.org/10.3390/ijms241512206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418939/
https://www.ncbi.nlm.nih.gov/pubmed/37569582
http://dx.doi.org/10.3390/ijms241512206

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