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Synthesis, (123)I-Radiolabeling Optimization, and Initial Preclinical Evaluation of Novel Urea-Based PSMA Inhibitors with a Tributylstannyl Prosthetic Group in Their Structures
Prostate-specific membrane antigen (PSMA) has been identified as a target for the development of theranostic agents. In our current work, we describe the design and synthesis of novel N-[N-[(S)-1,3-dicarboxypropyl]carbamoyl]-(S)-L-lysine (DCL) urea-based PSMA inhibitors with a chlorine-substituted a...
Autores principales: | Hasnowo, Lutfi A., Larkina, Maria S., Plotnikov, Evgenii, Bodenko, Vitalina, Yuldasheva, Feruza, Stasyuk, Elena, Petrov, Stanislav A., Zyk, Nikolai Y., Machulkin, Aleksei E., Vorozhtsov, Nikolai I., Beloglazkina, Elena K., Nenajdenko, Valentine G., Tolmachev, Vladimir, Orlova, Anna, Majouga, Alexander G., Yusubov, Mekhman S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418939/ https://www.ncbi.nlm.nih.gov/pubmed/37569582 http://dx.doi.org/10.3390/ijms241512206 |
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