Actions of a Novel Bacterial Topoisomerase Inhibitor against Neisseria gonorrhoeae Gyrase and Topoisomerase IV: Enhancement of Double-Stranded DNA Breaks

Novel bacterial topoisomerase inhibitors (NBTIs) are an emerging class of antibacterials that target gyrase and topoisomerase IV. A hallmark of NBTIs is their ability to induce gyrase/topoisomerase IV-mediated single-stranded DNA breaks and suppress the generation of double-stranded breaks. However,...

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Detalles Bibliográficos
Autores principales: Dauda, Soziema E., Collins, Jessica A., Byl, Jo Ann W., Lu, Yanran, Yalowich, Jack C., Mitton-Fry, Mark J., Osheroff, Neil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419083/
https://www.ncbi.nlm.nih.gov/pubmed/37569485
http://dx.doi.org/10.3390/ijms241512107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419083/
https://www.ncbi.nlm.nih.gov/pubmed/37569485
http://dx.doi.org/10.3390/ijms241512107

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