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Recent advances in analysis of capsaicin and its effects on metabolic pathways by mass spectrometry

Capsaicin is the main food active component in Capsicum that has gained considerable attention due to its broad biological activities, including antioxidation, anti-inflammation, anti-tumor, weight regulation, cardiac protection, anti-calculi, and diurnal-circadian regulation. The potent biological...

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Autores principales: Peng, Zifang, Zhang, Wenfen, Zhang, Xu, Mao, Jian, Zhang, Qidong, Zhao, Wuduo, Zhang, Shusheng, Xie, Jianping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419207/
https://www.ncbi.nlm.nih.gov/pubmed/37575327
http://dx.doi.org/10.3389/fnut.2023.1227517
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author Peng, Zifang
Zhang, Wenfen
Zhang, Xu
Mao, Jian
Zhang, Qidong
Zhao, Wuduo
Zhang, Shusheng
Xie, Jianping
author_facet Peng, Zifang
Zhang, Wenfen
Zhang, Xu
Mao, Jian
Zhang, Qidong
Zhao, Wuduo
Zhang, Shusheng
Xie, Jianping
author_sort Peng, Zifang
collection PubMed
description Capsaicin is the main food active component in Capsicum that has gained considerable attention due to its broad biological activities, including antioxidation, anti-inflammation, anti-tumor, weight regulation, cardiac protection, anti-calculi, and diurnal-circadian regulation. The potent biological effects of capsaicin are intimately related to metabolic pathways such as lipid metabolism, energy metabolism, and antioxidant stress. Mass spectrometry (MS) has emerged as an effective tool for deciphering the mechanisms underlying capsaicin metabolism and its biological impacts. However, it remains challenging to accurately identify and quantify capsaicin and its self-metabolites in complex food and biological samples, and to integrate multi-omics data generated from MS. In this work, we summarized recent advances in the detection of capsaicin and its self-metabolites using MS and discussed the relevant MS-based studies of metabolic pathways. Furthermore, we discussed current issues and future directions in this field. In-depth studies of capsaicin metabolism and its physiological functions based on MS is anticipated to yield new insights and methods for preventing and treating a wide range of diseases.
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spelling pubmed-104192072023-08-12 Recent advances in analysis of capsaicin and its effects on metabolic pathways by mass spectrometry Peng, Zifang Zhang, Wenfen Zhang, Xu Mao, Jian Zhang, Qidong Zhao, Wuduo Zhang, Shusheng Xie, Jianping Front Nutr Nutrition Capsaicin is the main food active component in Capsicum that has gained considerable attention due to its broad biological activities, including antioxidation, anti-inflammation, anti-tumor, weight regulation, cardiac protection, anti-calculi, and diurnal-circadian regulation. The potent biological effects of capsaicin are intimately related to metabolic pathways such as lipid metabolism, energy metabolism, and antioxidant stress. Mass spectrometry (MS) has emerged as an effective tool for deciphering the mechanisms underlying capsaicin metabolism and its biological impacts. However, it remains challenging to accurately identify and quantify capsaicin and its self-metabolites in complex food and biological samples, and to integrate multi-omics data generated from MS. In this work, we summarized recent advances in the detection of capsaicin and its self-metabolites using MS and discussed the relevant MS-based studies of metabolic pathways. Furthermore, we discussed current issues and future directions in this field. In-depth studies of capsaicin metabolism and its physiological functions based on MS is anticipated to yield new insights and methods for preventing and treating a wide range of diseases. Frontiers Media S.A. 2023-07-28 /pmc/articles/PMC10419207/ /pubmed/37575327 http://dx.doi.org/10.3389/fnut.2023.1227517 Text en Copyright © 2023 Peng, Zhang, Zhang, Mao, Zhang, Zhao, Zhang and Xie. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Peng, Zifang
Zhang, Wenfen
Zhang, Xu
Mao, Jian
Zhang, Qidong
Zhao, Wuduo
Zhang, Shusheng
Xie, Jianping
Recent advances in analysis of capsaicin and its effects on metabolic pathways by mass spectrometry
title Recent advances in analysis of capsaicin and its effects on metabolic pathways by mass spectrometry
title_full Recent advances in analysis of capsaicin and its effects on metabolic pathways by mass spectrometry
title_fullStr Recent advances in analysis of capsaicin and its effects on metabolic pathways by mass spectrometry
title_full_unstemmed Recent advances in analysis of capsaicin and its effects on metabolic pathways by mass spectrometry
title_short Recent advances in analysis of capsaicin and its effects on metabolic pathways by mass spectrometry
title_sort recent advances in analysis of capsaicin and its effects on metabolic pathways by mass spectrometry
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419207/
https://www.ncbi.nlm.nih.gov/pubmed/37575327
http://dx.doi.org/10.3389/fnut.2023.1227517
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