Pneumonia, lymphocytes and C-reactive protein are valuable tests for predicting surgical intervention in necrotizing enterocolitis

BACKGROUND: Necrotizing enterocolitis (NEC) is one of the important causes of neonatal death, and proper timing of operation is of critical significance. This study aimed to explore the high-risk factors for NEC requiring surgical intervention and to provide a reference for its clinical diagnosis an...

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Autores principales: Yu, Daiyue, Yang, Huirong, Zhong, Chen, Fan, Kaisi, Zeng, Guichang, Zhang, Mengzhen, Zhao, Qianyun, Yang, Jiaming, Yang, Liucheng, Wu, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419212/
https://www.ncbi.nlm.nih.gov/pubmed/37576139
http://dx.doi.org/10.3389/fped.2023.1231627
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author Yu, Daiyue
Yang, Huirong
Zhong, Chen
Fan, Kaisi
Zeng, Guichang
Zhang, Mengzhen
Zhao, Qianyun
Yang, Jiaming
Yang, Liucheng
Wu, Kai
author_facet Yu, Daiyue
Yang, Huirong
Zhong, Chen
Fan, Kaisi
Zeng, Guichang
Zhang, Mengzhen
Zhao, Qianyun
Yang, Jiaming
Yang, Liucheng
Wu, Kai
author_sort Yu, Daiyue
collection PubMed
description BACKGROUND: Necrotizing enterocolitis (NEC) is one of the important causes of neonatal death, and proper timing of operation is of critical significance. This study aimed to explore the high-risk factors for NEC requiring surgical intervention and to provide a reference for its clinical diagnosis and treatment. METHODS: Clinical and radiological evidence of NEC neonates admitted to Zhujiang Hospital of Southern Medical University and Zhongshan Boai Hospital from January 2010 to October 2022 were retrospectively analyzed. Patients were divided into surgical group and conservative group according to whether they underwent surgery or not. Univariate analysis of the clinical data of the two groups was conducted, and multivariate logistic regression analysis was then performed for statistically significant results in the univariate analysis. RESULTS: 267 infants were included in this study, of which 90 patients underwent surgical intervention for NEC and 177 conservation treatment. The univariate analysis showed that the gestational age, pneumonia, leukocytes, lymphocytes, erythrocytes, platelets, C-reactive protein, and blood glucose were statistically significant in the surgical group compared to the conservative group (All P < 0.05). Furthermore, the results of multivariate logistic regression analysis showed that compared to the conservative group, patients in the surgical group had a higher proportion of pneumonia (OR = 2.098; 95% CI: 1.030-4.272; P = 0.041), lower lymphocyte values (OR = 0.749; 95% CI: 0.588-0.954; P = 0.019), and higher C-reactive protein values (OR = 1.009; 95% CI: 1.003-1.016; P = 0.004). CONCLUSIONS: Pneumonia, decreased lymphocytes, and elevated C-reactive protein are potential high-risk factors for neonates with NEC requiring surgical intervention and may have potential clinical implications for predicting surgical risk.
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spelling pubmed-104192122023-08-12 Pneumonia, lymphocytes and C-reactive protein are valuable tests for predicting surgical intervention in necrotizing enterocolitis Yu, Daiyue Yang, Huirong Zhong, Chen Fan, Kaisi Zeng, Guichang Zhang, Mengzhen Zhao, Qianyun Yang, Jiaming Yang, Liucheng Wu, Kai Front Pediatr Pediatrics BACKGROUND: Necrotizing enterocolitis (NEC) is one of the important causes of neonatal death, and proper timing of operation is of critical significance. This study aimed to explore the high-risk factors for NEC requiring surgical intervention and to provide a reference for its clinical diagnosis and treatment. METHODS: Clinical and radiological evidence of NEC neonates admitted to Zhujiang Hospital of Southern Medical University and Zhongshan Boai Hospital from January 2010 to October 2022 were retrospectively analyzed. Patients were divided into surgical group and conservative group according to whether they underwent surgery or not. Univariate analysis of the clinical data of the two groups was conducted, and multivariate logistic regression analysis was then performed for statistically significant results in the univariate analysis. RESULTS: 267 infants were included in this study, of which 90 patients underwent surgical intervention for NEC and 177 conservation treatment. The univariate analysis showed that the gestational age, pneumonia, leukocytes, lymphocytes, erythrocytes, platelets, C-reactive protein, and blood glucose were statistically significant in the surgical group compared to the conservative group (All P < 0.05). Furthermore, the results of multivariate logistic regression analysis showed that compared to the conservative group, patients in the surgical group had a higher proportion of pneumonia (OR = 2.098; 95% CI: 1.030-4.272; P = 0.041), lower lymphocyte values (OR = 0.749; 95% CI: 0.588-0.954; P = 0.019), and higher C-reactive protein values (OR = 1.009; 95% CI: 1.003-1.016; P = 0.004). CONCLUSIONS: Pneumonia, decreased lymphocytes, and elevated C-reactive protein are potential high-risk factors for neonates with NEC requiring surgical intervention and may have potential clinical implications for predicting surgical risk. Frontiers Media S.A. 2023-07-28 /pmc/articles/PMC10419212/ /pubmed/37576139 http://dx.doi.org/10.3389/fped.2023.1231627 Text en © 2023 Yu, Yang, Zhong, Fan, Zeng, Zhang, Zhao, Yang, Yang and Wu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Yu, Daiyue
Yang, Huirong
Zhong, Chen
Fan, Kaisi
Zeng, Guichang
Zhang, Mengzhen
Zhao, Qianyun
Yang, Jiaming
Yang, Liucheng
Wu, Kai
Pneumonia, lymphocytes and C-reactive protein are valuable tests for predicting surgical intervention in necrotizing enterocolitis
title Pneumonia, lymphocytes and C-reactive protein are valuable tests for predicting surgical intervention in necrotizing enterocolitis
title_full Pneumonia, lymphocytes and C-reactive protein are valuable tests for predicting surgical intervention in necrotizing enterocolitis
title_fullStr Pneumonia, lymphocytes and C-reactive protein are valuable tests for predicting surgical intervention in necrotizing enterocolitis
title_full_unstemmed Pneumonia, lymphocytes and C-reactive protein are valuable tests for predicting surgical intervention in necrotizing enterocolitis
title_short Pneumonia, lymphocytes and C-reactive protein are valuable tests for predicting surgical intervention in necrotizing enterocolitis
title_sort pneumonia, lymphocytes and c-reactive protein are valuable tests for predicting surgical intervention in necrotizing enterocolitis
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419212/
https://www.ncbi.nlm.nih.gov/pubmed/37576139
http://dx.doi.org/10.3389/fped.2023.1231627
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