Dihydroxyphenylacetaldehyde Lowering Treatment Improves Locomotor and Neurochemical Abnormalities in the Rat Rotenone Model: Relevance to the Catecholaldehyde Hypothesis for the Pathogenesis of Parkinson’s Disease

The catecholaldehyde hypothesis for the pathogenesis of Parkinson’s disease centers on accumulation of 3,4-dihydroxyphenylacetaldehyde (DOPAL) in dopaminergic neurons. To test the hypothesis, it is necessary to reduce DOPAL and assess if this improves locomotor abnormalities. Systemic administration...

Descripción completa

Detalles Bibliográficos
Autores principales: Khashab, Rawan, Gutman-Sharabi, Naama, Shabtai, Zehava, Landau, Regev, Halperin, Reut, Fay-Karmon, Tsviya, Leibowitz, Avshalom, Sharabi, Yehonatan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419703/
https://www.ncbi.nlm.nih.gov/pubmed/37569897
http://dx.doi.org/10.3390/ijms241512522

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10419703/
https://www.ncbi.nlm.nih.gov/pubmed/37569897
http://dx.doi.org/10.3390/ijms241512522

Ejemplares similares